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Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report.
Jassem, Jacek; Marek-Trzonkowska, Natalia Maria; Smiatacz, Tomasz; Arcimowicz, Lukasz; Papak, Ines; Jassem, Ewa; Zaucha, Jan Maciej.
  • Jassem J; Department of Oncology and Radiotherapy, Medical University of Gdansk, 80-214 Gdansk, Poland.
  • Marek-Trzonkowska NM; International Centre for Cancer Vaccine Science, University of Gdansk, 80-822 Gdansk, Poland.
  • Smiatacz T; Laboratory of Immunoregulation and Cellular Therapies, Department of Family Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.
  • Arcimowicz L; Department of Infectious Diseases, Medical University of Gdansk, 80-214 Gdansk, Poland.
  • Papak I; International Centre for Cancer Vaccine Science, University of Gdansk, 80-822 Gdansk, Poland.
  • Jassem E; International Centre for Cancer Vaccine Science, University of Gdansk, 80-822 Gdansk, Poland.
  • Zaucha JM; Department of Pneumonology, Medical University of Gdansk, 80-214 Gdansk, Poland.
Int J Mol Sci ; 22(20)2021 Oct 10.
Article in English | MEDLINE | ID: covidwho-1463713
ABSTRACT
We report a lymphoma patient with profound B-cell deficiency after chemotherapy combined with anti-CD20 antibody successfully treated with remdesivir and convalescent plasma for prolonged SARS-CoV-2 infection. Viral clearance was likely attributed to the robust expansion and activation of TCR Vß2 CD8+ cytotoxic T cells and CD16 + CD56- NK cells. This is the first presentation of TCR-specific T cell oligoclonal response in COVID-19. Our study suggests that B-cell depleted patients may effectively respond to anti-SARS-CoV-2 treatment when NK and antigen-specific Tc cell response is induced.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Killer Cells, Natural / T-Lymphocytes, Cytotoxic / COVID-19 Type of study: Case report Limits: Aged / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222010934

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Killer Cells, Natural / T-Lymphocytes, Cytotoxic / COVID-19 Type of study: Case report Limits: Aged / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Ijms222010934