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Cardiometabolic Disorders and the Risk of Critical COVID-19 as Compared to Influenza Pneumonia.
Fayol, Antoine; Livrozet, Marine; Pereira, Héléna; Diehl, Jean-Luc; Lebeaux, David; Arlet, Jean-Benoit; Cholley, Bernard; Carette, Claire; Carves, Jean-Baptiste; Czernichow, Sébastien; Hauw, Caroline; Hamada, Sophie-Rym; Jannot, Anne-Sophie; Volle, Geoffroy; Masurkar, Nihar; Mirault, Tristan; Planquette, Benjamin; Sanchez, Olivier; Châtellier, Gilles; Azizi, Michel; Hulot, Jean-Sébastien.
  • Fayol A; Université de Paris, F-75006 Paris, France.
  • Livrozet M; CIC1418 and DMU CARTE, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Européen Georges-Pompidou, F-75015 Paris, France.
  • Pereira H; INSERM, Paris Cardiovascular Research Center, PARCC, UMR970, F-75015 Paris, France.
  • Diehl JL; Université de Paris, F-75006 Paris, France.
  • Lebeaux D; CIC1418 and DMU CARTE, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Européen Georges-Pompidou, F-75015 Paris, France.
  • Arlet JB; INSERM, Paris Cardiovascular Research Center, PARCC, UMR970, F-75015 Paris, France.
  • Cholley B; Université de Paris, F-75006 Paris, France.
  • Carette C; Clinical and Epidemiological Unit, AP-HP, Hôpital Européen Georges-Pompidou, F-75015 Paris, France.
  • Carves JB; Université de Paris, F-75006 Paris, France.
  • Czernichow S; Medical Intensive Care Unit, AP-HP, Hôpital Européen Georges-Pompidou, F-75015 Paris, France.
  • Hauw C; Université de Paris, F-75006 Paris, France.
  • Hamada SR; Service de Microbiologie, Unité Mobile d'Infectiologie, AP-HP, Hôpital Européen Georges-Pompidou, F-75015 Paris, France.
  • Jannot AS; Université de Paris, F-75006 Paris, France.
  • Volle G; Internal Medicine Department, Sickle Cell Referral Center, AP-HP, Hôpital Européen Georges-Pompidou, F-75015 Paris, France.
  • Masurkar N; Université de Paris, F-75006 Paris, France.
  • Mirault T; Department of Anesthesia and Intensive Care, AP-HP, Hôpital Européen Georges-Pompidou, F-75015 Paris, France.
  • Planquette B; Université de Paris, F-75006 Paris, France.
  • Sanchez O; Service de Nutrition, Centre Spécialisé Obésité, AP-HP, Hôpital Européen Georges-Pompidou, F-75015 Paris, France.
  • Châtellier G; Université de Paris, F-75006 Paris, France.
  • Azizi M; CIC1418 and DMU CARTE, Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Européen Georges-Pompidou, F-75015 Paris, France.
  • Hulot JS; Université de Paris, F-75006 Paris, France.
J Clin Med ; 10(19)2021 Oct 08.
Article in English | MEDLINE | ID: covidwho-1463727
ABSTRACT
We aimed to compare the influence of cardiometabolic disorders on the incidence of severe COVID-19 vs. non-COVID pneumonia. We included all consecutive patients admitted with SARS-CoV-2-positive pneumonia between 12 March 2020 and 1 April 2020 and compared them to patients with influenza pneumonia hospitalized between December 2017 and December 2019 at the same tertiary hospital in Paris. Patients with COVID-19 were significantly younger and more frequently male. In the analysis adjusted for age and sex, patients with COVID-19 were more likely to be obese (adjOR 2.25; 95% CI 1.24-4.09; p = 0.0076) and receive diuretics (adjOR 2.13; 95% CI 1.12-4.03; p = 0.021) but were less likely to be smokers (adjOR 0.40; 95% CI 0.24-0.64; p = 0.0002), have COPD (adjOR 0.25; 95% CI 0.11-0.56; p = 0.0008), or have a previous or active cancer diagnosis (adjOR 0.54, 95% CI 0.32-0.91; p = 0.020). The rate of ICU admission was significantly higher in patients with COVID-19 (32.4% vs. 5.2% p < 0.0001). Obesity was significantly associated with the risk of direct ICU admission in patients with COVID-19 but not in patients with influenza pneumonia. Likewise, pre-existing hypertension was significantly associated with mortality in patients with COVID-19 but not in patients with influenza pneumonia. Cardiometabolic disorders differentially influenced the risk of presenting with severe COVID-19 or influenza pneumonia.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10194618

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10194618