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The Effects of Previous Asthma and COPD on the Susceptibility to and Severity of COVID-19: A Nationwide Cohort Study in South Korea.
Jung, Younghee; Wee, Jee Hye; Kim, Joo-Hee; Choi, Hyo Geun.
  • Jung Y; Division of Infectious Diseases, Department of Internal Medicine, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
  • Wee JH; Department of Otorhinolaryngology, College of Medicine, Hallym University, Anyang 14068, Korea.
  • Kim JH; Division of Pulmonary, Allergy and Critical Care Medicine Department of Medicine, Hallym University Sacred Heart Hospital, College of Medicine, Hallym University, Anyang 14068, Korea.
  • Choi HG; Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Hallym University, Anyang 14068, Korea.
J Clin Med ; 10(20)2021 Oct 09.
Article in English | MEDLINE | ID: covidwho-1463728
ABSTRACT

BACKGROUND:

There is controversial evidence of the associations of asthma and chronic obstructive pulmonary disease (COPD) with the risk and outcomes of Coronavirus Disease 2019 (COVID-19). We aimed to evaluate the effects of asthma and COPD on the susceptibility to and severity of COVID-19.

METHODS:

Data from a nationwide COVID-19 cohort database by the Korea National Health Insurance Corporation were utilized. A total of 4066 COVID-19 patients (1 January 2020 through 4 June 2020) were 14 matched with 16,264 controls with regard to age, sex, and income. Asthma and COPD were defined as diagnostic codes (ICD-10) and medication claim codes. Conditional and unconditional multivariate logistic regression were applied to analyze the susceptibility to and severity of COVID-19 associated with asthma and COPD.

RESULTS:

The prevalence of mild and severe asthma/COPD did not differ between the COVID-19 and control patients in the multivariate analyses. Among the total 4066 COVID-19 patients, 343 (8.4%) had severe COVID-19, of whom 132 (3.2% of the total COVID-19 patients) died. Regarding the outcomes of COVID-19, neither mild nor severe asthma were associated with the severity or mortality of COVID-19 after adjusting for other variables. However, severe COPD was a significant risk factor for severe COVID-19 (odds ratio (OR) = 2.23, 95% confidence intervals (CI) 1.08-4.60, p = 0.030) and the mortality of COVID-19 in the multivariate analyses (OR = 3.06, 95% CI 1.14-8.2, p = 0.026).

CONCLUSIONS:

In a Korean nationwide cohort, neither asthma nor COPD were associated with COVID-19, but severe COPD was associated with the severity and mortality of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Risk factors Language: English Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Risk factors Language: English Year: 2021 Document Type: Article