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Virucidal Effect of the Mesoscopic Structure of CAC-717 on Severe Acute Respiratory Syndrome Coronavirus-2.
Yokoyama, Takashi; Nishimura, Tomoyasu; Uwamino, Yoshifumi; Kosaki, Kenjiro; Furusaki, Koichi; Onishi, Rumiko; Onodera, Takashi; Haritani, Makoto; Sugiura, Katsuaki; Kirisawa, Rikio; Hasegawa, Naoki.
  • Yokoyama T; Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
  • Nishimura T; Department of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Uwamino Y; Department of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Kosaki K; Department of Infectious Diseases, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Furusaki K; Center for Medical Genetics, Keio University School of Medicine, Tokyo 160-8582, Japan.
  • Onishi R; Mineral Activation Technical Research Center, Kumamoto 865-0023, Japan.
  • Onodera T; Santa Mineral Co., Ltd., Tokyo 105-0013, Japan.
  • Haritani M; Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
  • Sugiura K; Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
  • Kirisawa R; School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan.
  • Hasegawa N; Environmental Science for Sustainable Development, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan.
Microorganisms ; 9(10)2021 Oct 04.
Article in English | MEDLINE | ID: covidwho-1463761
ABSTRACT
Here, the virucidal effect of calcium bicarbonate with a mesoscopic structure (CAC-717) on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was determined. Assays showed that CAC-717 had a strong virucidal effect on all examined SARS-CoV-2 isolates, including variant strains. The viral infectivity decreased within 15 s, and the virucidal activity of CAC-717 at a 149 ratio was similar to that of ethanol disinfectant. CAC-717 neutralization eliminated this virucidal effect, indicating that the alkaline condition of CAC-717 is important for virus inactivation and is an indicator of its mesoscopic structure and virucidal activity. The virucidal effect was observed in the presence of organic matter (bovine serum albumin). CAC-717 is a non-invasive and non-flammable substance with a low environmental burden, and its usefulness as a novel disinfectant has been confirmed.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Variants Language: English Year: 2021 Document Type: Article Affiliation country: Microorganisms9102096

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Variants Language: English Year: 2021 Document Type: Article Affiliation country: Microorganisms9102096