Total Syntheses of Pladienolide-Derived Spliceosome Modulators.
Molecules
; 26(19)2021 Sep 30.
Article
in English
| MEDLINE | ID: covidwho-1463765
ABSTRACT
Pladienolides, an emerging class of naturally occurring spliceosome modulators, exhibit interesting structural features, such as highly substituted 12-membered macrocycles and epoxide-containing diene side chains. The potential of pladienolides as anti-cancer agents is confirmed by H3B-8800, a synthetic analog of this natural product class, which is currently under Phase I clinical trials. Since its isolation in 2004 and the first total synthesis in 2007, a dozen total syntheses and synthetic approaches toward the pladienolide class have been reported to date. This review focuses on the eight completed total syntheses of naturally occurring pladienolides or their synthetic analogs, in addition to a synthetic approach to the main framework of the natural product.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Biological Products
/
Spliceosomes
/
Macrolides
/
Epoxy Compounds
/
Neoplasms
/
Antineoplastic Agents, Phytogenic
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal subject:
Biology
Year:
2021
Document Type:
Article
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