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Longitudinal Humoral Responses after COVID-19 Vaccination in Peritoneal and Hemodialysis Patients over Twelve Weeks.
Speer, Claudius; Schaier, Matthias; Nusshag, Christian; Töllner, Maximilian; Buylaert, Mirabel; Kälble, Florian; Reichel, Paula; Grenz, Julia; Süsal, Caner; Zeier, Martin; Schnitzler, Paul; Morath, Christian; Klein, Katrin; Benning, Louise.
  • Speer C; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Schaier M; Molecular Medicine Partnership Unit Heidelberg, EMBL, 69120 Heidelberg, Germany.
  • Nusshag C; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Töllner M; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Buylaert M; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Kälble F; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Reichel P; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Grenz J; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Süsal C; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Zeier M; Institute of Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Schnitzler P; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Morath C; Department of Infectious Diseases, Virology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Klein K; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
  • Benning L; Department of Nephrology, University Hospital Heidelberg, 69120 Heidelberg, Germany.
Vaccines (Basel) ; 9(10)2021 Oct 04.
Article in English | MEDLINE | ID: covidwho-1463844
ABSTRACT
It has been demonstrated that patients on hemo- or peritoneal dialysis are particularly susceptible to SARS-CoV-2 infection and impaired seroconversion compared to healthy controls. Follow-up data on vaccination response in dialysis patients is limited but is greatly needed to individualize and guide (booster) vaccination strategies. In this prospective, multicenter study we measured anti-spike S1 and neutralizing antibodies in 124 hemodialysis patients, 41 peritoneal dialysis patients, and 20 age- and sex-matched healthy controls over 12 weeks after homologous BNT162b2 vaccination. Compared to healthy controls, both hemodialysis and peritoneal dialysis patients had lower anti-S1 IgG antibodies (median (IQR) 7.0 (2.8-24.3) and 21.8 (5.8-103.9) versus 134.9 (23.8-283.6), respectively; p < 0.001 and p < 0.05) and a reduced SARS-CoV-2 spike protein-ACE2 binding inhibition caused by vaccine-induced antibodies (median (IQR) 56% (40-81) and 77% (52-89) versus 96% (90-98), respectively; p < 0.001 and p < 0.01) three weeks after the second vaccination. Twelve weeks after the second vaccination, the spike protein-ACE2 binding inhibition significantly decreased to a median (IQR) of 45% (31-60) in hemodialysis patients and 55% (36-78) in peritoneal dialysis patients, respectively (p < 0.001 and p < 0.05). Peritoneal dialysis patients mounted higher antibody levels compared with hemodialysis patients at all time points during the 12-week follow-up. Individual booster vaccinations in high-risk individuals without seroconversion or rapidly waning neutralizing antibody levels are required and further data on the neutralization of emerging variants of concern in these patients are urgently needed.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9101130

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines / Variants Language: English Year: 2021 Document Type: Article Affiliation country: Vaccines9101130