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[The Liver Injury and Coagulation Dysfunction in the Patients with Severe/Critical COVID-19].
Zhang, Jie; Gao, Xiao-Ling; Liu, Yan; Jiang, Yi; Jia, Zhi-Mei; Zhao, Fang-Fang; Xu, Dong; Huo, Li-Juan; Yang, Lin-Hua.
  • Zhang J; Shanxi Medical University Taiyuan 030001, Shanxi Province, China,Department of Gastroenterology, The First Hospital of Shanxi Medical University Taiyuan 030001, Shanxi Province, China.
  • Gao XL; Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, Shanxi Province, China.
  • Liu Y; Department of Critical Care Medicine, The First Hospital of Shanxi Medical University Taiyuan 030001, Shanxi Province, China.
  • Jiang Y; Department of Respiratory and Critical Care Medicine, The First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China.
  • Jia ZM; Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, Shanxi Province, China.
  • Zhao FF; Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, Shanxi Province, China.
  • Xu D; Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
  • Huo LJ; Department of Gastroenterology, The First Hospital of Shanxi Medical University Taiyuan 030001, Shanxi Province, China.
  • Yang LH; Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China,E-mail: yanglh5282@163.com.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 29(5): 1582-1588, 2021 Oct.
Article in Chinese | MEDLINE | ID: covidwho-1464140
ABSTRACT
Abstract

Objective:

To analyze the liver injury and coagulation dysfunction in COVID-19 severe/critical type patients.

METHODS:

The clinical data of 53 COVID-19 patients were collected from a single center in Wuhan from February 8, 2020 to March 25, 2020. The patients were divided into severe type group (38 patients) and critical type group (15 patients). The clinical characteristics, indexes of liver function, coagulation function and inflammatory markers were analyzed retrospectively. According to the degree of abnormal liver function in the process of diagnosis and treatment, the patients were divided into three groups combined liver injury, mild abnormal liver function and normal liver function group. Statistical analysis was performed by using Student t test, Mann-Whitney U test, Kruskal-Wallis test and Chi-square test.

RESULTS:

Among the 53 patients, 29 were male (54.7%) and 24 were female (45.3%), the median age was 57(27-80) years old. The time from onset to admission was (11.5±7.7) days. The levels of AST, TBIL, DBIL, ALP, GGT, LDH, D-dimer, PCT and hsCRP in critical patients were higher than those in severe patients (P<0.05). The levels of Alb in critical patients was lower than those in severe patients (P<0.05). Among the 53 patients, 34 (64%) patients showed abnormal elevation of ALT, AST or TBIL, while 4 (7.5%) patients showed the criteria of COVID-19 with liver injury. After the patients were grouping according to the degree of liver dysfunction, the levels of ALP, GGT and D-dimer of the patients in the liver injury group were significantly higher than those in the normal liver function group, D-dimer levels of the patients in the liver injury group was significantly higher than those in the mild abnormal liver function group, while the levels of ALP and GGT in the mild abnormal liver function group were significantly higher than those in the normal liver function group, and the differences were statistically significant(P<0.05).

CONCLUSION:

In this group, the patients with COVID-19 severe/critical type have a certain proportion of liver injury accompanied by significantly increased D-dimer levels, critical type patients have more severe liver function and coagulation dysfunction, which may promote the progression of COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Blood Coagulation Disorders / COVID-19 Subject: Blood Coagulation Disorders / COVID-19 Type of study: Observational study Language: Chinese Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Blood Coagulation Disorders / COVID-19 Subject: Blood Coagulation Disorders / COVID-19 Type of study: Observational study Language: Chinese Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi Year: 2021
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