A co(Ii)-schiff base complex: Crystal structure and application values on sars-cov-2 induced acute lung injury

ABSTRACT

In the present study, a new Co(II)-Schiff base complex, [Co(HL)2Cl2] (1), [Schiff base (HL) = 2-(2-methoxybenzylideneamino)phenol] has been successfully prepared by reaction of Co(II) chloride hexahydrate with the Schiff base ligand HL in a mixed solvent of aqueous-methanolic solution via a slow evaporation synthesis method. For the treatment of SARS-COV-2 induced acute lung injury, the ELISA detection kit was performed in the research to measure the content of inflammatory cytokines TNF-α and IFN-γ released into the alveolar lavage fluid. In addition to this, the activation levels of the prolyl carboxypeptidase in the alveolar epithelial cells were determined with real time RT-PCR.