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Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs.
Maheden, Kieran; Todd, Brendan; Gordon, Calvin J; Tchesnokov, Egor P; Götte, Matthias.
  • Maheden K; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada.
  • Todd B; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
  • Gordon CJ; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
  • Tchesnokov EP; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
  • Götte M; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada; Li Ka Shing Institute of Virology at University of Alberta, Edmonton, AB, Canada. Electronic address: gotte@ualberta.ca.
Enzymes ; 49: 315-354, 2021.
Article in English | MEDLINE | ID: covidwho-1464553
ABSTRACT
The treatment of viral infections remains challenging, in particular in the face of emerging pathogens. Broad-spectrum antiviral drugs could potentially be used as a first line of defense. The RNA-dependent RNA polymerase (RdRp) of RNA viruses serves as a logical target for drug discovery and development efforts. Herein we discuss compounds that target RdRp of poliovirus, hepatitis C virus, influenza viruses, respiratory syncytial virus, and the growing data on coronaviruses. We focus on nucleotide analogs and mechanisms of action and resistance.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Viruses / RNA-Dependent RNA Polymerase / Viral Replicase Complex Proteins / Nucleotides Type of study: Prognostic study Language: English Journal: Enzymes Year: 2021 Document Type: Article Affiliation country: Bs.enz.2021.07.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Viruses / RNA-Dependent RNA Polymerase / Viral Replicase Complex Proteins / Nucleotides Type of study: Prognostic study Language: English Journal: Enzymes Year: 2021 Document Type: Article Affiliation country: Bs.enz.2021.07.002