Inhibition of viral RNA-dependent RNA polymerases with clinically relevant nucleotide analogs.
Enzymes
; 49: 315-354, 2021.
Article
in English
| MEDLINE | ID: covidwho-1464553
ABSTRACT
The treatment of viral infections remains challenging, in particular in the face of emerging pathogens. Broad-spectrum antiviral drugs could potentially be used as a first line of defense. The RNA-dependent RNA polymerase (RdRp) of RNA viruses serves as a logical target for drug discovery and development efforts. Herein we discuss compounds that target RdRp of poliovirus, hepatitis C virus, influenza viruses, respiratory syncytial virus, and the growing data on coronaviruses. We focus on nucleotide analogs and mechanisms of action and resistance.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Viruses
/
RNA-Dependent RNA Polymerase
/
Viral Replicase Complex Proteins
/
Nucleotides
Type of study:
Prognostic study
Language:
English
Journal:
Enzymes
Year:
2021
Document Type:
Article
Affiliation country:
Bs.enz.2021.07.002
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