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Utility of P-SEP, sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection.
Dholariya, Sagar; Parchwani, Deepak N; Singh, Ragini; Radadiya, Madhuri; Katoch, C D S.
  • Dholariya S; All India Institute of Medical Sciences, Rajkot, Gujarat India.
  • Parchwani DN; All India Institute of Medical Sciences, Rajkot, Gujarat India.
  • Singh R; All India Institute of Medical Sciences, Rajkot, Gujarat India.
  • Radadiya M; PDU Medical College, Rajkot, Gujarat India.
  • Katoch CDS; All India Institute of Medical Sciences, Rajkot, Gujarat India.
Indian J Clin Biochem ; 37(2): 131-138, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1465913
ABSTRACT
The coronavirus disease 2019 is a highly contagious viral infection caused by SARS-CoV-2 virus, member of coronaviridae family. It causes life threatening complications due to complexity and rapid onset course of the disease. Early identification of high-risk patients who require close monitoring and aggressive treatment remains challengeable till date. Novel biomarkers which help to identify high risk patients at the early stage is high priority. Objective of this review to find utility of P-SEP, sTREM-1 and suPAR for diagnosis, risk stratification and prognosis of SARS-CoV-2 infected cases. Soluble receptors like, P-SEP, sTREM-1 and suPAR have been involved in immune regulation in SARS-CoV-2 infection and elevate more in severe cases. A comprehensive research of databases like PubMed, EMBASE, CNKI and Web of Science was performed for relevant studies. A total of nine out of fifteen research literature in initial screening were included for this review. Interestingly all studies have reported high levels of P-SEP, sTREM-1 and suPAR in SARS-CoV-2 infected cases and the biomarkers positively correlated with severity of infection. This implies that P-SEP, sTREM-1 and suPAR can be implemented as surrogate marker in blood profile for early diagnosis, risk stratification and prognosis in SARS-CoV-2 for better management in Indian population at the current situation.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study / Reviews Language: English Journal: Indian J Clin Biochem Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Prognostic study / Reviews Language: English Journal: Indian J Clin Biochem Year: 2022 Document Type: Article