Comparing the outcomes of treatment with INF-ß 1-a (interferon beta-1a) and IFN-ß 1-b (interferon beta-1b) among COVID-19 inpatients.
Int Immunopharmacol
; 101(Pt B): 108241, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1466416
ABSTRACT
BACKGROUND:
IFNßs are known as one of the most promising drugs used for COVID-19 treatment. This study aimed to investigate the effects of treatment with INF-ß 1-a (interferon beta-1a) and IFN-ß 1-b (interferon beta-1b) on COVID-19 inpatients.METHODS:
In this study, we retrospectively evaluated the clinical treatment outcomes of 100 patients with COVID-19 who received IFN-ß 1-a and IFN-ß 1-b during their hospitalization period. The rate of discharge from the hospital was considered equal to the clinical improvement and then evaluated as a primary outcome. Moreover, mortality, ICU admission and length of ICU stay, frequency of intubation and use of mechanical ventilation, duration of hospitalization, laboratory factors, and medications were assessed as secondary outcomes.RESULTS:
The median discharge time of IFN-ß 1a recipients was approximately equal to that of IFN-ß 1-b recipients as 9 (5-10) days and 7 (5-11) days, respectively (HR = 2.43, P = 0.75). Mortality rate was also estimated as 10% among IFN-ß 1-a recipients and 14% among IFN-ß 1-b recipients, which was not statistically significant (p = 0.190). ICU hospitalization rate for the IFN-ß 1-a recipients and IFN-ß 1-b recipients was 26% and 36%, respectively. In addition, no significant difference was found between these two intervention groups in terms of ICU length of stay (1 (0-2) vs. 1 (0-4.25(, respectively,) P = 0.357). There was no significant difference between the two study groups in terms of frequency of mechanical ventilation and length of hospital stay.CONCLUSION:
There was no significant difference between the two groups in terms of shortening the disease time, clinical improvements and other outcomes.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Interferon beta-1a
/
Interferon beta-1b
/
SARS-CoV-2
/
COVID-19 Drug Treatment
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Int Immunopharmacol
Journal subject:
Allergy and Immunology
/
Pharmacology
Year:
2021
Document Type:
Article
Affiliation country:
J.intimp.2021.108241
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