Long-term (>48 weeks) safety and tolerability of erenumab in real-life
Journal of the Neurological Sciences
; 429, 2021.
Article
in English
| EMBASE | ID: covidwho-1466683
ABSTRACT
Background and aims:
Erenumab proved to be safe and well tolerated in a 5-year continuation of a 1-year double-blind, placebo-controlled study.Aim:
to assess >48-week erenumab tolerability and safety in a real-world setting.Methods:
In this long term (>48-week), multicenter (n = 15), longitudinal cohort real life study, we monitored all the adverse events emerged in consecutive adult patients with high-frequency episodic migraine (HFEM) or chronic migraine (CM) treated with monthly erenumab 70 mg or 140 mg from 20 December 2018 to 15 December 2020.Results:
442 patients (HFEM 115;CM 327) were treated with erenumab for >48 weeks 209 (47.3%) patients were treated for 49–60 weeks, 132 (29.9%) for 61–72 weeks;73 (16.5%) for 73–84 weeks;21 (4.7%) for 85–100 weeks. Overall, >1 treatment emergent adverse event (TEAE) was reported by 136 (30.8%) [HFEM 43 (37.4%);CM 93 (28.4%)]. Most common TEAE were constipation (n = 66;14.9%), injection site erythema (n = 15;3.4%), and influenza (n = 7;1.6%). Serious adverse events (SAE) were reported by 8 patients (1.8%) and led to treatment discontinuation severe constipation (n = 3), abdominal pain (n = 1), NSTEMI (n = 3), Covid-19 infection (n = 1). Only severe constipation was considered treatment-related SAE (0.45%).Conclusions:
Conclusion:
Erenumab is safe and well tolerated also in long-term treatment (>48 weeks) in real life.
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Journal of the Neurological Sciences
Year:
2021
Document Type:
Article
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