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SARS-CoV-2 infection associated with monoclonal gammopathy. A case report based on the study of minimally invasive ultrasound-guided autopsy.
González-García, María Del Carmen; Pérez Montero, Pablo; Pena Burgos, Eva Manuela; Vega Cabrera, Cristina; Hernández Cabrero, Teresa; Rivas Becerra, Begoña; Yébenes, Laura; Hardisson, David.
  • González-García MDC; Department of Pathology, La Paz University Hospital, Madrid, Spain. Electronic address: carmen.gonzalezgarcia@yahoo.es.
  • Pérez Montero P; Department of Pathology, La Paz University Hospital, Madrid, Spain.
  • Pena Burgos EM; Department of Pathology, La Paz University Hospital, Madrid, Spain.
  • Vega Cabrera C; Department of Nephrology, La Paz University Hospital, Madrid, Spain.
  • Hernández Cabrero T; Department of Radiology, La Paz University Hospital, Madrid, Spain.
  • Rivas Becerra B; Department of Nephrology, La Paz University Hospital, Madrid, Spain.
  • Yébenes L; Department of Pathology, La Paz University Hospital, Madrid, Spain.
  • Hardisson D; Department of Pathology, La Paz University Hospital, Madrid, Spain.
Rev Esp Patol ; 55(1): 41-45, 2022.
Article in English | MEDLINE | ID: covidwho-1466827
ABSTRACT
Coronavirus disease-2019 (COVID-19) is a global public health emergency with numerous clinical facets, including acute kidney injury and acute cerebrovascular disease. Further knowledge of its various pathogenic mechanisms is essential, including coagulation disorders. Monoclonal gammopathy is characterized by the overproduction of a monoclonal immunoglobulin caused by clonal proliferation. Using a postmortem study of ultrasound-guided percutaneous core biopsies, the aim of this report is to present our observations on the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection pathology associated with monoclonal gammopathy. The clinical presentation was acute renal failure. Pathological findings revealed kappa light chain cast nephropathy. SARS-CoV-2 immunohistochemistry was positive in some renal tubular cells. Another notable finding was the presence of a high density of alveolar megakaryocytes, which probably explained the final outcome (acute cerebrovascular disease). Immunohistochemical study for SARS-CoV-2 does not verify the pathogenic effect of the virus and thus its contribution to the acute kidney injury.
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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Paraproteinemias / COVID-19 Subject: Paraproteinemias / COVID-19 Type of study: Case report / Risk factors Language: English Journal: Rev Esp Patol Year: 2022

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Paraproteinemias / COVID-19 Subject: Paraproteinemias / COVID-19 Type of study: Case report / Risk factors Language: English Journal: Rev Esp Patol Year: 2022
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