What Do COVID-19 Vaccines Tell Us About Nucleic Acid Delivery In Vivo?
Nucleic Acid Ther
; 31(5): 321-323, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1467290
ABSTRACT
The utilization of the mRNA-based Pfizer-BioNTech and Moderna coronavirus disease 2019 (COVID-19) vaccines represents the culmination of many years of nonviral nucleic acid delivery, but more importantly, they signify a massive clinical scientific success. Scientists working in the area of nucleic acid delivery using lipid nanoparticles will undoubtedly be energized by the success of these vaccines and begin to collect much needed data in the realm of nonviral-based RNA and DNA delivery, specifically, the use of lipid nanoparticles, the immune response, safety, and efficacy. It is easily conceivable that in the future we can utilize these data to help streamline our approach for the delivery of DNA for gene therapy and regulatory RNAs for therapeutic and regenerative medicine (ie, wound repair) applications.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
DNA
/
RNA, Messenger
/
Gene Transfer Techniques
/
COVID-19 Vaccines
/
COVID-19
Type of study:
Prognostic study
/
Reviews
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Nucleic Acid Ther
Year:
2021
Document Type:
Article
Affiliation country:
NAT.2021.0013
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