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What Do COVID-19 Vaccines Tell Us About Nucleic Acid Delivery In Vivo?
Hadjiargyrou, Michael.
  • Hadjiargyrou M; Department of Biological and Chemical Sciences, New York Institute of Technology, Old Westbury, New York, USA.
Nucleic Acid Ther ; 31(5): 321-323, 2021 10.
Article in English | MEDLINE | ID: covidwho-1467290
ABSTRACT
The utilization of the mRNA-based Pfizer-BioNTech and Moderna coronavirus disease 2019 (COVID-19) vaccines represents the culmination of many years of nonviral nucleic acid delivery, but more importantly, they signify a massive clinical scientific success. Scientists working in the area of nucleic acid delivery using lipid nanoparticles will undoubtedly be energized by the success of these vaccines and begin to collect much needed data in the realm of nonviral-based RNA and DNA delivery, specifically, the use of lipid nanoparticles, the immune response, safety, and efficacy. It is easily conceivable that in the future we can utilize these data to help streamline our approach for the delivery of DNA for gene therapy and regulatory RNAs for therapeutic and regenerative medicine (ie, wound repair) applications.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: DNA / RNA, Messenger / Gene Transfer Techniques / COVID-19 Vaccines / COVID-19 Type of study: Prognostic study / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Nucleic Acid Ther Year: 2021 Document Type: Article Affiliation country: NAT.2021.0013

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Full text: Available Collection: International databases Database: MEDLINE Main subject: DNA / RNA, Messenger / Gene Transfer Techniques / COVID-19 Vaccines / COVID-19 Type of study: Prognostic study / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Nucleic Acid Ther Year: 2021 Document Type: Article Affiliation country: NAT.2021.0013