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Oral Microbiome Alterations and SARS-CoV-2 Saliva Viral Load in Patients with COVID-19.
Miller, Emily Happy; Annavajhala, Medini K; Chong, Alexander M; Park, Heekuk; Nobel, Yael R; Soroush, Ali; Blackett, John W; Krigel, Anna; Phipps, Meaghan M; Freedberg, Daniel E; Zucker, Jason; Sano, Ellen D; Uhlemann, Anne-Catrin; Abrams, Julian A.
  • Miller EH; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Annavajhala MK; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Chong AM; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Park H; Microbiome and Pathogen Genomics Collaborative Center, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Nobel YR; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Soroush A; Microbiome and Pathogen Genomics Collaborative Center, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Blackett JW; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Krigel A; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Phipps MM; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Freedberg DE; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Zucker J; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Sano ED; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Uhlemann AC; Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Abrams JA; Department of Emergency Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Microbiol Spectr ; 9(2): e0005521, 2021 10 31.
Article in English | MEDLINE | ID: covidwho-1467670
ABSTRACT
Bacterial-viral interactions in saliva have been associated with morbidity and mortality for respiratory viruses such as influenza and SARS-CoV. However, such transkingdom relationships during SARS-CoV-2 infection are currently unknown. Here, we aimed to elucidate the relationship between saliva microbiota and SARS-CoV-2 in a cohort of newly hospitalized COVID-19 patients and controls. We used 16S rRNA sequencing to compare microbiome diversity and taxonomic composition between COVID-19 patients (n = 53) and controls (n = 59) and based on saliva SARS-CoV-2 viral load as measured using reverse transcription PCR (RT-PCR). The saliva microbiome did not differ markedly between COVID-19 patients and controls. However, we identified significant differential abundance of numerous taxa based on saliva SARS-CoV-2 viral load, including multiple species within Streptococcus and Prevotella. IMPORTANCE Alterations to the saliva microbiome based on SARS-CoV-2 viral load indicate potential biologically relevant bacterial-viral relationships which may affect clinical outcomes in COVID-19 disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Bacteria / Microbial Interactions / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Language: English Journal: Microbiol Spectr Year: 2021 Document Type: Article Affiliation country: Spectrum.00055-21

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Bacteria / Microbial Interactions / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Language: English Journal: Microbiol Spectr Year: 2021 Document Type: Article Affiliation country: Spectrum.00055-21