[Research progress on antibody-dependent enhancement in infectious diseases].
Zhonghua Yu Fang Yi Xue Za Zhi
; 55(2): 171-176, 2021 Feb 06.
Article
in Chinese
| MEDLINE | ID: covidwho-1468517
ABSTRACT
Antibody-dependent enhancement (ADE) refers to the process in which some virus-specific antibodies (generally non-neutralizing antibodies) bind to the virus and bind to some cells expressing FcR on the surface through their Fc segment, thereby mediating the endocytosis and replication of the virus and enhancing the infection of the virus. This review summarized experience of ADE in respiratory syncytial virus, dengue virus, influenza virus infection and explored the possible mechanism of COVID-19 high incidence and severity of the disease, which implied challenges in the process of vaccine development and provided some insights for COVID-19 pathogenesis.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Dengue
/
Dengue Virus
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
Chinese
Journal:
Zhonghua Yu Fang Yi Xue Za Zhi
Year:
2021
Document Type:
Article
Affiliation country:
Cma.j.cn112150-20200820-01141
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