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[Development and outlook on human challenge trial of vaccine].
Han, B F; Huang, N H; Chen, L Y; Zhao, T S; Liu, H Y; Zhang, S H; Wang, Y; Zheng, H; Liu, B; Wang, C; Liu, Y Q; Lu, Q B; Cui, F Q.
  • Han BF; School of Public Health, Peking University, Beijing 100191, China.
  • Huang NH; School of Public Health, Peking University, Beijing 100191, China.
  • Chen LY; School of Public Health, Peking University, Beijing 100191, China.
  • Zhao TS; School of Public Health, Peking University, Beijing 100191, China.
  • Liu HY; School of Public Health, Peking University, Beijing 100191, China.
  • Zhang SH; School of Public Health, Peking University, Beijing 100191, China.
  • Wang Y; School of Public Health, Peking University, Beijing 100191, China.
  • Zheng H; School of Public Health, Peking University, Beijing 100191, China National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
  • Liu B; School of Public Health, Peking University, Beijing 100191, China.
  • Wang C; School of Public Health, Peking University, Beijing 100191, China.
  • Liu YQ; School of Public Health, Peking University, Beijing 100191, China.
  • Lu QB; School of Public Health, Peking University, Beijing 100191, China.
  • Cui FQ; School of Public Health, Peking University, Beijing 100191, China.
Zhonghua Liu Xing Bing Xue Za Zhi ; 42(8): 1371-1375, 2021 Aug 10.
Article in Chinese | MEDLINE | ID: covidwho-1468526
ABSTRACT
Human challenge trial (HCT) is a test in which human volunteers are intentionally infected with pathogens in order to evaluate the efficacy of candidate preventive or therapeutic drugs. During the COVID-19 pandemic, the HCT of vaccines has aroused people's attention due to its significant advantages over clinical trial. This paper introduces the concept, development and application of HCT, the advantages and limitations of HCT for vaccine evaluation, and the consideration of future HCT of COVID-19 vaccine in China.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: Chinese Journal: Zhonghua Liu Xing Bing Xue Za Zhi Year: 2021 Document Type: Article Affiliation country: Cma.j.cn112338-20210506-00368

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: Chinese Journal: Zhonghua Liu Xing Bing Xue Za Zhi Year: 2021 Document Type: Article Affiliation country: Cma.j.cn112338-20210506-00368