Association of circadian clock and severe acute respiratory syndrome coronavirus 2 infection

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing devastation worldwide accounting millions of deaths. This virus is among the new member of the Coronaviridae family with differences from SARS-CoV. The entry of the virus to human cells mediated through spike (S) proteins with angiotensin-converting enzyme 2 (ACE2). Several comorbidities such as hypertension, diabetes, HIV, malignancy, diabetes, chronic respiratory disease, and cardiovascular disease makes a person susceptible to COVID-19 infection. Circadian rhythm/oscillations or biological clock plays important role in the pathogenesis of SARS-CoV-2 infection mediated through ACE2 and BMAL1. Copyright © 2021 Korean Academy of Sleep Medicine.