Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets.
Viruses
; 13(10)2021 10 14.
Article
in English
| MEDLINE | ID: covidwho-1469382
ABSTRACT
Respiratory viruses are known to be the most frequent causative mediators of lung infections in humans, bearing significant impact on the host cell signaling machinery due to their host-dependency for efficient replication. Certain cellular functions are actively induced by respiratory viruses for their own benefit. This includes metabolic pathways such as glycolysis, fatty acid synthesis (FAS) and the tricarboxylic acid (TCA) cycle, among others, which are modified during viral infections. Here, we summarize the current knowledge of metabolic pathway modifications mediated by the acute respiratory viruses respiratory syncytial virus (RSV), rhinovirus (RV), influenza virus (IV), parainfluenza virus (PIV), coronavirus (CoV) and adenovirus (AdV), and highlight potential targets and compounds for therapeutic approaches.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Tract Infections
/
Citric Acid Cycle
/
Energy Metabolism
/
Fatty Acids
/
Glycolysis
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
V13102068
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