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Whole-organ transdermal photobiomodulation (PBM) of COVID-19: A 50-patient case study.
Williams, Richard K; Raimondo, John; Cahn, David; Williams, Aldon; Schell, Daniel.
  • Williams RK; Applied BioPhotonics Ltd., Cupertino, California, USA.
  • Raimondo J; Pulmonair, San Antonio, Texas, USA.
  • Cahn D; O'Connor Hospital, San Jose, California, USA.
  • Williams A; Advanced Spinal Pain Management, Boerne, Texas, USA.
  • Schell D; LightMD, Inc., Cupertino, California, USA.
J Biophotonics ; 15(2): e202100194, 2022 02.
Article in English | MEDLINE | ID: covidwho-1469461
ABSTRACT
A nonrandomized 50-person case study of COVID-19-positive patients was conducted employing (for the first time) a regimen of whole-organ deep-tissue transdermal dynamic photobiomodulation (PBM) as a primary (or exclusive) therapeutic modality in the treatment of coronavirus. Therapy sessions comprised algorithmically alternating red (650 nm) and near-infrared (NIR; 850 nm) LEDs with an average irradiance of 11 mW/cm2 dynamically sequenced at multiple pulse frequencies. Delivered via 3D bendable polymeric pads maintaining orthogonal optical incidence to body contours over 1,000 cm2 , a single 84-minute session concurrently delivered 20 kJ to the sinuses and 15 kJ to each lung at skin temperatures below 42°C. Therapeutic outcomes observed include significant reductions in the duration and severity of disease symptoms. Acute conditions including fever, body aches (BA) and respiratory distress comprising paroxysmal coughing; lung congestion, dyspnea and hypoxia; sinus congestion; acute eye inflammation; and extreme malaise were eliminated in 41/50 patients within 4 days of commencing PBM treatments with 50/50 patients fully recovering within 3 weeks with no supplemental oxygen requirements. SpO2 concentrations improved as much as 9 points (average 2.5 points) across the entire study population. The PBM sessions required to completely resolve COVID-19 conditions appears monotonically correlated to the time-to-treatment (TTTx)-the delay between the onset of a patient's symptoms and commencing PBM therapy. In contrast, acute inflammatory symptoms were resolved within 4 days irrespective of TTTx.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Low-Level Light Therapy / COVID-19 Type of study: Case report / Observational study / Prognostic study Limits: Humans Language: English Journal: J Biophotonics Journal subject: Biophysics Year: 2022 Document Type: Article Affiliation country: Jbio.202100194

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Low-Level Light Therapy / COVID-19 Type of study: Case report / Observational study / Prognostic study Limits: Humans Language: English Journal: J Biophotonics Journal subject: Biophysics Year: 2022 Document Type: Article Affiliation country: Jbio.202100194