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Pulmonary vascular system: A vulnerable target for COVID-19.
Ai, Jiayuan; Hong, Weiqi; Wu, Min; Wei, Xiawei.
  • Ai J; Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu Sichuan PR China.
  • Hong W; Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu Sichuan PR China.
  • Wu M; Department of Biomedical Sciences School of Medicine and Health Sciences University of North Dakota Grand Forks North Dakota USA.
  • Wei X; Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy National Clinical Research Center for Geriatrics West China Hospital Sichuan University Chengdu Sichuan PR China.
MedComm (2020) ; 2(4): 531-547, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1469531
ABSTRACT
The number of coronavirus disease 2019 (COVID-19) cases has been increasing significantly, and the disease has evolved into a global pandemic, posing an unprecedented challenge to the healthcare community. Angiotensin-converting enzyme 2, the binding and entry receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in hosts, is also expressed on pulmonary vascular endothelium; thus, pulmonary vasculature is a potential target in COVID-19. Indeed, pulmonary vascular thickening is observed by early clinical imaging, implying a tropism of SARS-CoV-2 for pulmonary vasculature. Recent studies reported that COVID-19 is associated with vascular endothelial damage and dysfunction along with inflammation, coagulopathy, and microthrombosis; all of these pathologic changes are the hallmarks of pulmonary vascular diseases. Notwithstanding the not fully elucidated effects of COVID-19 on pulmonary vasculature, the vascular endotheliopathy that occurs after infection is attributed to direct infection and indirect damage mainly caused by renin-angiotensin-aldosterone system imbalance, coagulation cascade, oxidative stress, immune dysregulation, and intussusceptive angiogenesis. Degradation of endothelial glycocalyx exposes endothelial cell (EC) surface receptors to the vascular lumen, which renders pulmonary ECs more susceptible to SARS-CoV-2 infection. The present article reviews the potential pulmonary vascular pathophysiology and clinical presentations in COVID-19 to provide a basis for clinicians and scientists, providing insights into the development of therapeutic strategies targeting pulmonary vasculature.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: MedComm (2020) Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: MedComm (2020) Year: 2021 Document Type: Article