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Role of ACE2-Ang (1-7)-Mas axis in post-COVID-19 complications and its dietary modulation.
Sahu, Santoshi; Patil, C R; Kumar, Sachin; Apparsundaram, Subbu; Goyal, Ramesh K.
  • Sahu S; Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University (DPDRU), PushpVihar Sector-3, New Delhi, 110017, India.
  • Patil CR; Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University (DPDRU), PushpVihar Sector-3, New Delhi, 110017, India.
  • Kumar S; Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University (DPDRU), PushpVihar Sector-3, New Delhi, 110017, India.
  • Apparsundaram S; Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University (DPDRU), PushpVihar Sector-3, New Delhi, 110017, India.
  • Goyal RK; Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University (DPDRU), PushpVihar Sector-3, New Delhi, 110017, India. goyalrk@gmail.com.
Mol Cell Biochem ; 477(1): 225-240, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1469743
ABSTRACT
Severe acute respiratory syndrome-coronavirus-2 (COVID-19) virus uses Angiotensin-Converting Enzyme 2 (ACE2) as a gateway for their entry into the human body. The ACE2 with cleaved products have emerged as major contributing factors to multiple physiological functions and pathogenic complications leading to the clinical consequences of the COVID-19 infection Decreased ACE2 expression restricts the viral entry into the human cells and reduces the viral load. COVID-19 infection reduces the ACE2 expression and induces post-COVID-19 complications like pneumonia and lung injury. The modulation of the ACE2-Ang (1-7)-Mas (AAM) axis is also being explored as a modality to treat post-COVID-19 complications. Evidence indicates that specific food components may modulate the AAM axis. The variations in the susceptibility to COVID-19 infection and the post-COVID its complications are being correlated with varied dietary habits. Some of the food substances have emerged to have supportive roles in treating post-COVID-19 complications and are being considered as adjuvants to the COVID-19 therapy. It is possible that some of their active ingredients may emerge as the direct treatment for the COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptide Fragments / Angiotensin I / Angiotensin-Converting Enzyme 2 / COVID-19 / Proto-Oncogene Mas Topics: Long Covid Limits: Humans Language: English Journal: Mol Cell Biochem Year: 2022 Document Type: Article Affiliation country: S11010-021-04275-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptide Fragments / Angiotensin I / Angiotensin-Converting Enzyme 2 / COVID-19 / Proto-Oncogene Mas Topics: Long Covid Limits: Humans Language: English Journal: Mol Cell Biochem Year: 2022 Document Type: Article Affiliation country: S11010-021-04275-2