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The effect of COVID-19 derived cytokine storm on cancer cells progression: double-edged sword.
Heydarian, Mohammad; Mohammadtaghizadeh, Mohammadjavad; Shojaei, Mahboobeh; Babazadeh, Marziyeh; Abbasian, Sadegh; Amrovani, Mehran.
  • Heydarian M; Lorestan University of Medical Sciences, Khorramabad, Iran.
  • Mohammadtaghizadeh M; Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Shojaei M; High Institute for Education and Research in Transfusion Medicine, Tehran, Iran.
  • Babazadeh M; Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Abbasian S; Department of Laboratory Science, School of Paramedical Sciences, Ilam University of Medical Sciences, Ilam, Iran.
  • Amrovani M; High Institute for Education and Research in Transfusion Medicine, Tehran, Iran. e.amrovani@gmail.com.
Mol Biol Rep ; 49(1): 605-615, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1469744
ABSTRACT

OBJECTIVE:

Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) was first detected in Wuhan, China in December, 2019. The emerging virus causes a respiratory illness, that can trigger a cytokine storm in the body.

METHOD:

Cytokine storm in patient's body is associated with severe forms of disease. It is one of the main complications of coronavirus disease-2019 (COVID-19), in which immune cells play a major role. Studies have shown immune cells in the tumor environment can be effective to induce resistance to chemotherapy in cancer patients.

RESULT:

Therefore, considering the role of immune cells to induce cytokine storm in COVID-19 patients, and their role to cause resistance to chemotherapy, they are effective on disease progression and creation of severe form of disease.

CONCLUSION:

By examining the signaling pathways and inducing resistance to chemotherapy in tumor cells and the cells affect them, it is possible to prevent the occurrence of severe forms of the disease in cancer patients with COVID-19; it is applicable using target therapy and other subsequent treatment strategies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / COVID-19 / Neoplasms Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Mol Biol Rep Year: 2022 Document Type: Article Affiliation country: S11033-021-06800-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cytokine Release Syndrome / COVID-19 / Neoplasms Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: Mol Biol Rep Year: 2022 Document Type: Article Affiliation country: S11033-021-06800-4