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INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants.
Andrade, Viviane M; Christensen-Quick, Aaron; Agnes, Joseph; Tur, Jared; Reed, Charles; Kalia, Richa; Marrero, Idania; Elwood, Dustin; Schultheis, Katherine; Purwar, Mansi; Reuschel, Emma; McMullan, Trevor; Pezzoli, Patrick; Kraynyak, Kim; Sylvester, Albert; Mammen, Mammen P; Tebas, Pablo; Joseph Kim, J; Weiner, David B; Smith, Trevor R F; Ramos, Stephanie J; Humeau, Laurent M; Boyer, Jean D; Broderick, Kate E.
  • Andrade VM; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Christensen-Quick A; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Agnes J; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Tur J; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Reed C; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Kalia R; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Marrero I; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Elwood D; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Schultheis K; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Purwar M; Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, USA.
  • Reuschel E; Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, USA.
  • McMullan T; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Pezzoli P; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Kraynyak K; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Sylvester A; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Mammen MP; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Tebas P; Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
  • Joseph Kim J; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Weiner DB; Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA, USA.
  • Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Ramos SJ; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Humeau LM; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Boyer JD; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA.
  • Broderick KE; Inovio Pharmaceuticals, Plymouth Meeting, PA, USA. Kate.Broderick@inovio.com.
NPJ Vaccines ; 6(1): 121, 2021 Oct 14.
Article in English | MEDLINE | ID: covidwho-1469970
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Topics: Vaccines / Variants Language: English Journal: NPJ Vaccines Year: 2021 Document Type: Article Affiliation country: S41541-021-00384-7

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study Topics: Vaccines / Variants Language: English Journal: NPJ Vaccines Year: 2021 Document Type: Article Affiliation country: S41541-021-00384-7