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Radiation Inactivation of Coronavirus Infection Pathogen by the Example of Transmissible Gastroenteritis Virus.
Morozov, V N; Mukhin, A N; Kolyvanova, M A; Belousov, A V; Bushmanov, Y A; Grebennikova, T V; Samoylov, A S.
  • Morozov VN; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia.
  • Mukhin AN; Gamaleya Federal Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.
  • Kolyvanova MA; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia.
  • Belousov AV; Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency, 123182 Moscow, Russia.
  • Bushmanov YA; Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency, 123182 Moscow, Russia.
  • Grebennikova TV; Burnasyan Federal Medical Biophysical Center, Federal Medical Biological Agency, 123182 Moscow, Russia.
  • Samoylov AS; Gamaleya Federal Research Center for Epidemiology and Microbiology, 123098 Moscow, Russia.
Biophysics (Oxf) ; 66(4): 589-595, 2021.
Article in English | MEDLINE | ID: covidwho-1470498
ABSTRACT
In recent years, members of the Coronaviridae family have caused outbreaks of respiratory diseases (MERS, SARS, and COVID-19). At the same time, the potential of radiation-induced inactivation of this group of viruses have been little studied, although radiation technologies can be widely used both in the processing of personal protective equipment and in the sterilization of vaccines. In the present work, the effect of 10 MeV electron beams and 7.6 MeV bremsstrahlung on the coronavirus infection pathogen (transmissible gastroenteritis virus) has been studied in vitro. In the given experimental conditions, irradiation with photons turned out to be more effective. The virus-containing suspension frozen at -86°C was the most resistant to radiation the dose required for complete inactivation of the virus in this case was from 15 kGy, while for the liquid suspension and lyophilized form the sterilizing dose was from 10 kGy. At lower radiation doses for all samples during passaging in cell culture, residual infectious activity of the virus was observed. These differences in the efficiency of inactivation of liquid and frozen virus-containing samples indicate a significant contribution of the direct effect of radiation.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Biophysics (Oxf) Year: 2021 Document Type: Article Affiliation country: S000635092104014X

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: Biophysics (Oxf) Year: 2021 Document Type: Article Affiliation country: S000635092104014X