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Quantifying Renin-Angiotensin-System Alterations in COVID-19.
Pucci, Fabrizio; Annoni, Filippo; Dos Santos, Robson Augusto Souza; Taccone, Fabio Silvio; Rooman, Marianne.
  • Pucci F; 3BIO-Computational Biology and Bioinformatics, Université Libre de Bruxelles, 1050 Brussels, Belgium.
  • Annoni F; (IB)2-Interuniversity Institute of Bioinformatics in Brussels, 1050 Brussels, Belgium.
  • Dos Santos RAS; Department of Intensive Care, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium.
  • Taccone FS; Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte 31270, MG, Brazil.
  • Rooman M; Department of Intensive Care, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Cells ; 10(10)2021 10 14.
Article in English | MEDLINE | ID: covidwho-1470799
ABSTRACT
The renin-angiotensin system (RAS) plays a pivotal role in a wide series of physiological processes, among which inflammation and blood pressure regulation. One of its key components, the angiotensin-converting enzyme 2, has been identified as the entry point of the SARS-CoV-2 virus into the host cells, and therefore a lot of research has been devoted to study RAS dysregulation in COVID-19. Here we discuss the alterations of the regulatory RAS axes due to SARS-CoV-2 infection on the basis of a series of recent clinical investigations and experimental analyzes quantifying, e.g., the levels and activity of RAS components. We performed a comprehensive meta-analysis of these data in view of disentangling the links between the impaired RAS functioning and the pathophysiological characteristics of COVID-19. We also review the effects of several RAS-targeting drugs and how they could potentially help restore the normal RAS functionality and minimize the COVID-19 severity. Finally, we discuss the conflicting evidence found in the literature and the open questions on RAS dysregulation in SARS-CoV-2 infection whose resolution would improve our understanding of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renin-Angiotensin System / COVID-19 Type of study: Prognostic study / Reviews Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10102755

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renin-Angiotensin System / COVID-19 Type of study: Prognostic study / Reviews Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10102755