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Real-Life Impact of Glucocorticoid Treatment in COVID-19 Mortality: A Multicenter Retrospective Study.
Muñoz-Gómez, Ana; Fernández-Cruz, Ana; Lavilla-Olleros, Cristina; Giner-Galvañ, Vicente; Ausín-García, Cristina; Wikman, Philip; Bendala-Estrada, Alejandro D; Vargas, Juan A; Rubio-Rivas, Manuel; Laureiro, Jaime; Fernández-Bermúdez, Daniel; Buonaiuto, Verónica A; Arenas de Larriva, Antonio P; Pascual-Pérez, María de Los Reyes; Alcalá-Pedrajas, José N; Labirua-Iturburu Ruiz, Ane; Hernández-Milián, Almudena; Gómez Del Mazo, Marta; Antequera, Beatriz; Mella-Pérez, Carmen; Navas-Alcántara, María de la Sierra; Soto-Delgado, Juan F; Gámez-Mancera, Rosa M; Sardiña-González, Cristina; Meijide-Míguez, Héctor; Ramos-Rincón, José M; Gómez-Huelgas, Ricardo.
  • Muñoz-Gómez A; Internal Medicine Department, Hospital de Parla, 28981 Madrid, Spain.
  • Fernández-Cruz A; Infectious Diseases Unit, Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, 28222 Madrid, Spain.
  • Lavilla-Olleros C; Internal Medicine Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
  • Giner-Galvañ V; Internal Medicine Department, Hospital Clínico Universitario de Sant Joan d'Alacant, Fundación para el Fomento de la Investigación Sanitaria y Biomédica en la Comunidad Valenciana (FISABIO), 03550 Alicante, Spain.
  • Ausín-García C; Internal Medicine Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
  • Wikman P; Internal Medicine Department, Hospital Clínico Universitario de Sant Joan d'Alacant, Fundación para el Fomento de la Investigación Sanitaria y Biomédica en la Comunidad Valenciana (FISABIO), 03550 Alicante, Spain.
  • Bendala-Estrada AD; Internal Medicine Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
  • Vargas JA; Internal Medicine Department, Hospital Universitario Puerta de Hierro-Majadahonda, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, 28222 Madrid, Spain.
  • Rubio-Rivas M; Department of Internal Medicine, Bellvitge University Hospital, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
  • Laureiro J; Doce de Octubre University Hospital, 28041 Madrid, Spain.
  • Fernández-Bermúdez D; Internal Medicine Department, Costa del Sol Hospital, 29603 Marbella, Spain.
  • Buonaiuto VA; Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), 29010 Málaga, Spain.
  • Arenas de Larriva AP; Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Av. Menendez Pidal s/n, 14004 Córdoba, Spain.
  • Pascual-Pérez MLR; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28222 Madrid, Spain.
  • Alcalá-Pedrajas JN; Internal Medicine Department, University General Hospital of Elda, 03600 Alicante, Spain.
  • Labirua-Iturburu Ruiz A; Internal Medicine Department, Pozoblanco Regional Hospital, 14400 Córdoba, Spain.
  • Hernández-Milián A; Santa Marina Hospital, 48004 Bilbao, Spain.
  • Gómez Del Mazo M; Internal Medicine Department, Son Llàtzer University Hospital, 07198 Palma de Mallorca, Spain.
  • Antequera B; Internal Medicine Department, San Pedro Hospital, 26006 Logroño, Spain.
  • Mella-Pérez C; Internal Medicine Department, Sagunto Hospital, 46520 Valencia, Spain.
  • Navas-Alcántara MS; Universitary Hospital Complex of Ferrol, 15405 A Coruña, Spain.
  • Soto-Delgado JF; Internal Medicine Department, Infanta Margarita Hospital, Cabra, 14940 Córdoba, Spain.
  • Gámez-Mancera RM; Internal Medicine Department, University Hospital of Salamanca, 37007 Salamanca, Spain.
  • Sardiña-González C; Internal Medicine Department, University Hospital Virgen del Rocío, 41013 Sevilla, Spain.
  • Meijide-Míguez H; Internal Medicine Department, Monforte de Lemos Public Hospital, 27400 Lugo, Spain.
  • Ramos-Rincón JM; Internal Medicine Department, Quironsalud Hospital, 15009 A Coruña, Spain.
  • Gómez-Huelgas R; Department of Clinical Medicine, Miguel Hernandez University of Elche, 03203 Alicante, Spain.
  • On Behalf Of The Semi-Covid-Network; Internal Medicine Department, Regional University Hospital of Málaga, Biomedical Research Institute of Málaga (IBIMA), University of Málaga (UMA), 29010 Málaga, Spain.
J Clin Med ; 10(20)2021 Oct 13.
Article in English | MEDLINE | ID: covidwho-1470898
ABSTRACT
We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patients not treated with corticosteroids; and adjusted using a propensity-score for steroid treatment. From March-July 2020, 5.262 (35.26%) were treated with corticosteroids and 9.659 (64.73%) were not. In-hospital mortality overall was 20.50%; it was higher in patients treated with corticosteroids than in controls (28.5% versus 16.2%, OR 2.068 [95% confidence interval; 1.908 to 2.242]; p = 0.0001); however, when adjusting by occurrence of ARDS, mortality was significantly lower in the steroid group (43.4% versus 57.6%; OR 0.564 [95% confidence interval; 0.503 to 0.633]; p = 0.0001). Moreover, the greater the respiratory failure, the greater the impact on mortality of the steroid treatment. When adjusting these results including the propensity score as a covariate, in-hospital mortality remained significantly lower in the steroid group (OR 0.774 [0.660 to 0.907], p = 0.002). Steroid treatment reduced mortality by 24% relative to no steroid treatment (RRR 0.24). These results support the use of glucocorticoids in COVID-19 in this subgroup of patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10204678

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10204678