Your browser doesn't support javascript.
COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis.
Borsche, Lorenz; Glauner, Bernd; von Mendel, Julian.
  • Borsche L; Independent Researcher, D-69117 Heidelberg, Germany.
  • Glauner B; Independent Researcher, D-72076 Tübingen, Germany.
  • von Mendel J; Artificial Intelligence, IU International University of Applied Sciences, D-99084 Erfurt, Germany.
Nutrients ; 13(10)2021 Oct 14.
Article in English | MEDLINE | ID: covidwho-1470937
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT

BACKGROUND:

Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic.

METHODS:

Systematic literature search was performed to identify retrospective cohort as well as clinical studies on COVID-19 mortality rates versus D3 blood levels. Mortality rates from clinical studies were corrected for age, sex, and diabetes. Data were analyzed using correlation and linear regression.

RESULTS:

One population study and seven clinical studies were identified, which reported D3 blood levels preinfection or on the day of hospital admission. The two independent datasets showed a negative Pearson correlation of D3 levels and mortality risk (r(17) = -0.4154, p = 0.0770/r(13) = -0.4886, p = 0.0646). For the combined data, median (IQR) D3 levels were 23.2 ng/mL (17.4-26.8), and a significant Pearson correlation was observed (r(32) = -0.3989, p = 0.0194). Regression suggested a theoretical point of zero mortality at approximately 50 ng/mL D3.

CONCLUSIONS:

The datasets provide strong evidence that low D3 is a predictor rather than just a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/mL to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Calcifediol / Nutritional Status / Cholecalciferol / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Nu13103596

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Calcifediol / Nutritional Status / Cholecalciferol / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Nu13103596