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Viral Shedding among Re-Positive Severe Acute Respiratory Syndrome Coronavirus-2 Positive Individuals in Republic of Korea.
Kim, Jeong-Min; Ryu, Boyeong; Choe, Young June; Jo, Hye-Jun; Lee, Hyeokjin; Kim, Heui Man; Lee, Nam-Joo; Rhee, Jee Eun; Chung, Yoon-Seok; Han, Myung-Guk; Kim, Eun-Jin; Park, Youngjoon; Gwack, Jin; Jin, Yeowon; Song, Jeongsuk; Seo, Seunghee; Gill, Byoungchul; Kim, Hyunyeong; Park, Yeeun; Yoo, Cheon Kwon; Jeong, Eun Kyeong.
  • Kim JM; Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Ryu B; Division of Risk Assessment, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Choe YJ; Department of Social and Preventive Medicine, Hallym University College of Medicine, Chuncheon-si 24252, Korea.
  • Jo HJ; Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Lee H; Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Kim HM; Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Lee NJ; Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Rhee JE; Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Chung YS; Honam Regional Center for Disease Control and Prevention, Division of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Seo-gu, Gwangju-si 61947, Korea.
  • Han MG; Division of Viral Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Kim EJ; Division of Emerging Infectious Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Park Y; Director for Epidemiological Investigation Analysis, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Gwack J; Division of Emerging Infectious Disease Response, Bureau of Infectious Disease Emergency Preparedness and Response, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Jin Y; Division of Emerging Infectious Disease Response, Bureau of Infectious Disease Emergency Preparedness and Response, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Song J; Division of Infectious Disease Control, Bureau of Infectious Disease Policy, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Seo S; Division of Laboratory Diagnosis Management, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Gill B; Division of Bacterial Diseases, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Kim H; Division of Laboratory Diagnosis Management, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Park Y; Division of Laboratory Diagnosis Management, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Yoo CK; Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
  • Jeong EK; Korea Disease Control and Prevention Agency, Cheongju-si 28159, Korea.
Viruses ; 13(10)2021 10 17.
Article in English | MEDLINE | ID: covidwho-1470999
ABSTRACT
This study investigated the infectivity of severe acute respiratory syndrome (SARS-CoV-2) in individuals who re-tested positive for SARS-CoV-2 RNA after recovering from their primary illness. We investigated 295 individuals with re-positive SARS-CoV-2 polymerase chain reaction (PCR) test results and 836 of their close contacts. We attempted virus isolation in individuals with re-positive SARS-CoV-2 PCR test results using cell culture and confirmed the presence of neutralizing antibodies using serological tests. Viral culture was negative in all 108 individuals with re-positive SARS-CoV-2 PCR test results in whom viral culture was performed. Three new cases of SARS-CoV-2 infection were identified among household contacts using PCR. Two of the three new cases had had contact with the index patient during their primary illness, and all three had antibody evidence of past infection. Thus, there was no laboratory evidence of viral shedding and no epidemiological evidence of transmission among individuals with re-positive SARS-CoV-2 PCR test results.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Shedding / Antibodies, Neutralizing / Reinfection / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Asia Language: English Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Shedding / Antibodies, Neutralizing / Reinfection / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Asia Language: English Year: 2021 Document Type: Article