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Monoclonal antibodies protect aged rhesus macaques from SARS-CoV-2-induced immune activation and neuroinflammation.
Verma, Anil; Hawes, Chase E; Lakshmanappa, Yashavanth Shaan; Roh, Jamin W; Schmidt, Brian A; Dutra, Joseph; Louie, William; Liu, Hongwei; Ma, Zhong-Min; Watanabe, Jennifer K; Usachenko, Jodie L; Immareddy, Ramya; Sammak, Rebecca L; Pollard, Rachel; Reader, J Rachel; Olstad, Katherine J; Coffey, Lark L; Kozlowski, Pamela A; Hartigan-O'Connor, Dennis J; Nussenzweig, Michel; Van Rompay, Koen K A; Morrison, John H; Iyer, Smita S.
  • Verma A; Center for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA.
  • Hawes CE; Center for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA; Graduate Group in Immunology, University of California, Davis, Davis, CA 95616, USA.
  • Lakshmanappa YS; Center for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA.
  • Roh JW; Center for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA; Graduate Group in Immunology, University of California, Davis, Davis, CA 95616, USA.
  • Schmidt BA; Center for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA.
  • Dutra J; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
  • Louie W; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
  • Liu H; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
  • Ma ZM; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
  • Watanabe JK; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
  • Usachenko JL; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
  • Immareddy R; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
  • Sammak RL; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
  • Pollard R; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA.
  • Reader JR; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
  • Olstad KJ; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
  • Coffey LL; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
  • Kozlowski PA; Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
  • Hartigan-O'Connor DJ; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
  • Nussenzweig M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
  • Van Rompay KKA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
  • Morrison JH; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Neurology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
  • Iyer SS; Center for Immunology and Infectious Diseases, University of California, Davis, Davis, CA 95616, USA; California National Primate Research Center, University of California, Davis, Davis, CA 95616, USA; Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University o
Cell Rep ; 37(5): 109942, 2021 11 02.
Article in English | MEDLINE | ID: covidwho-1471904
ABSTRACT
Anti-viral monoclonal antibody (mAb) treatments may provide immediate but short-term immunity from coronavirus disease 2019 (COVID-19) in high-risk populations, such as people with diabetes and the elderly; however, data on their efficacy in these populations are limited. We demonstrate that prophylactic mAb treatment blocks viral replication in both the upper and lower respiratory tracts in aged, type 2 diabetic rhesus macaques. mAb infusion dramatically curtails severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated stimulation of interferon-induced chemokines and T cell activation, significantly reducing development of interstitial pneumonia. Furthermore, mAb infusion significantly dampens the greater than 3-fold increase in SARS-CoV-2-induced effector CD4 T cell influx into the cerebrospinal fluid. Our data show that neutralizing mAbs administered preventatively to high-risk populations may mitigate the adverse inflammatory consequences of SARS-CoV-2 exposure.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Antibodies, Monoclonal Type of study: Prognostic study Topics: Long Covid Limits: Animals / Female / Humans / Male Language: English Journal: Cell Rep Year: 2021 Document Type: Article Affiliation country: J.celrep.2021.109942

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Antibodies, Monoclonal Type of study: Prognostic study Topics: Long Covid Limits: Animals / Female / Humans / Male Language: English Journal: Cell Rep Year: 2021 Document Type: Article Affiliation country: J.celrep.2021.109942