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Effect of parenteral nutrition in oxygen escalation/de-escalation in SARS-CoV-2 infected patients who are pre-intubation: A multicenter, observational study.
Subramanian, Kritika; Solomon, Nadia; Faillace, Robert; Menon, Vidya; Raiszadeh, Farbod; Brandeis, Gary.
  • Subramanian K; Department of Molecular Imaging and Therapeutics, Weill Cornell Medicine, New York, NY, USA; Department of Microbiology, Immunology and Transplantation, Laboratory of Clinical and Epidemiological Virology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
  • Solomon N; Department of Radiology, Yale University, New Haven, CT, USA.
  • Faillace R; Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
  • Menon V; Department of Medicine, Lincoln Hospital Center, Weill Cornell Medicine, Bronx, NY, USA.
  • Raiszadeh F; Division of Cardiology, Department of Medicine, Harlem Hospital Center, Columbia University, New York, NY, USA.
  • Brandeis G; Division of Geriatrics, Department of Medicine, Elmhurst Hospital Center, Icahn School of Medicine at Mount Sinai, Elmhurst, NY, USA; Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: brandeig@nychhc.org.
Clin Nutr ESPEN ; 46: 206-209, 2021 12.
Article in English | MEDLINE | ID: covidwho-1471923
ABSTRACT
BACKGROUND &

AIMS:

SARS-CoV-2 infection includes a variety of gastrointestinal manifestations along with the usual viral symptoms of malaise and myalgias. The objective of this study was to determine if intravenous parenteral nutrition (PN) affected the risk of intubation in SARS-CoV-2 patients who were dependent on non-invasive ventilation.

METHODS:

Retrospective, multicenter case-control study which analyzed oxygen requirements for 1974 adults with SARS-CoV-2, who were admitted to the local public hospital system between March 1 and May 17, 2020. Relevant baseline biomarkers were studied over 5 days. The main outcome was an escalation or de-escalation of oxygen requirements relative to the exposure of PN.

RESULTS:

111 patients received PN while on non-invasive ventilation. Patients who received PN had a significantly lower odds (p < 0.001) of oxygen escalation in comparison to their control group counterparts (OR = 0.804, 95% CI 0.720, 0.899) when matched for age, body mass index, Charlson comorbidity index, and gender.

CONCLUSION:

Initiating PN in the setting of non-invasive ventilation of SARS-CoV-2 infected patients was significantly associated with a lower odds of oxygen escalation. PN does not independently exacerbate oxygen requirements in SARS-CoV-2 infected pre-intubated patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: Clin Nutr ESPEN Year: 2021 Document Type: Article Affiliation country: J.clnesp.2021.10.007

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adult / Humans Language: English Journal: Clin Nutr ESPEN Year: 2021 Document Type: Article Affiliation country: J.clnesp.2021.10.007