Whole Exome Sequencing Identifies a Rare Mutation in NACAD as a Possible Cause of COVID Orchitis in Brothers.
Urology
; 159: 83-86, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1472193
ABSTRACT
COVID orchitis (testicular pain) is reported in 10-15% of men with long COVID. We identified 2 siblings with COVID orchitis and hypothesized that genetic mutations are associated with susceptibility. Blood samples from 5 COVID-19 (+) men, three of whom had orchitis were evaluated by whole-exome-sequencing. A rare deletion on chromosome 7 was found in NACAD among the 3 men with orchitis. Interestingly, circulating ACE2 levels was decreased in men with COVID orchitis. This pilot study generated the hypothesis that men who develop COVID orchitis could have underlying genetic variants and altered levels in circulating ACE2 that may increase their risk.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Orchitis
/
Chromosomes, Human, Pair 7
/
Chromosome Deletion
/
Exome Sequencing
/
COVID-19
Type of study:
Case report
/
Experimental Studies
/
Prognostic study
Topics:
Long Covid
/
Variants
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Urology
Year:
2022
Document Type:
Article
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