Hypoxia and viral infectious diseases.
JCI Insight
; 6(7)2021 04 08.
Article
in English
| MEDLINE | ID: covidwho-1472322
ABSTRACT
Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion. Conversely, HIFs are also implicated in the development of the host immune system and response to viral infections. Here, we highlight the recent revelations of host-pathogen interactions that involve the hypoxic response pathway and the role of HIF in emerging viral infectious diseases, as well as discussing potential antiviral therapeutic strategies targeting the HIF signaling axis.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Virus Diseases
/
Host-Pathogen Interactions
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Jci.insight.147190
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