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Hypoxia and viral infectious diseases.
Huang, Richard; Huestis, Melissa; Gan, Esther Shuyi; Ooi, Eng Eong; Ohh, Michael.
  • Huang R; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Huestis M; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Gan ES; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
  • Ooi EE; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.
  • Ohh M; Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore.
JCI Insight ; 6(7)2021 04 08.
Article in English | MEDLINE | ID: covidwho-1472322
ABSTRACT
Oxygen-sensing mechanisms allow cells to adapt and respond to changes in cellular oxygen tension, including hypoxic conditions. Hypoxia-inducible factor (HIF) is a central mediator in this fundamental adaptive response, and has critical functions in normal and disease physiology. Viruses have been shown to manipulate HIFs during their life cycle to facilitate replication and invasion. Conversely, HIFs are also implicated in the development of the host immune system and response to viral infections. Here, we highlight the recent revelations of host-pathogen interactions that involve the hypoxic response pathway and the role of HIF in emerging viral infectious diseases, as well as discussing potential antiviral therapeutic strategies targeting the HIF signaling axis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Virus Diseases / Host-Pathogen Interactions Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Jci.insight.147190

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Virus Diseases / Host-Pathogen Interactions Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Jci.insight.147190