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The role of vitamin D in prevention OF COVID-19 and its severity: an umbrella review.
Margarucci, Lory Marika; Montanari, Enrico; Gianfranceschi, Gianluca; Caprara, Claudio; Valeriani, Federica; Piccolella, Antonio; Lombardi, Valentina; Scaramucci, Elena; Romano Spica, Vincenzo.
  • Margarucci LM; University of Rome "Foro Italico", Rome, Italy. l.margarucci@studenti.uniroma4.it.
  • Montanari E; Scientific direction of "Elixir di Salute", Bologna, Italy. info@elisirdisalute.it.
  • Gianfranceschi G; University of Rome "Foro Italico", Rome, Italy. gianluca.gianfranceschi@uniroma4.it.
  • Caprara C; Scientific direction of "Elixir di Salute", Bologna, Italy. clcaprara@libero.it.
  • Valeriani F; University of Rome "Foro Italico", Rome, Italy. federica.valeriani@uniroma4.it.
  • Piccolella A; University Hospital "Agostino Gemelli" Foundation, Rome, Italy. piccolella@tin.it.
  • Lombardi V; University of Rome Tre, Rome, Italy. val.lombardi2@stud.uniroma3.it.
  • Scaramucci E; Sant'Andrea Hospital A.O.U., Sapienza University of Rome, Rome, Italy. elena.scaramucci@yahoo.it.
  • Romano Spica V; University of Rome "Foro Italico". vincenzo.romanospica@uniroma4.it.
Acta Biomed ; 92(S6): e2021451, 2021 10 01.
Article in English | MEDLINE | ID: covidwho-1472540
ABSTRACT
BACKGROUND AND

AIM:

Vitamin D is known to modulate immune response and its deficiency was associated with respiratory distress in patients hospitalized for pneumonia. Nevertheless, numerous reviews on vitamin D in COVID-19 patients have shown conflicting results, as previously reported also for other respiratory diseases (e.g., influenza).

METHODS:

This umbrella review aims to assess whether low serum 25-OHD is associated with susceptibility to COVID 19, their severity, and mortality. A total of 1559 studies were excluded after the title, abstract and full-text articles screening and 9 papers were included in this review 2 systematic reviews and 7 metanalysis.

RESULTS:

The findings of this review that summarized studies from 5 WHO regions (European Region, Region of the Americas, South-East Asia Region, Eastern Mediterranean Region, Western Pacific Region) to exclusion only African region, show that low serum 25-OHD levels are associated with higher infection risks for COVID-19.

CONCLUSIONS:

Although the umbrella findings indicate a potential role of vitamin D deficiency in COVID-19 severity in hospitalized patients and showing an association between Vitamin D supplementation and COVID-19 severity, however, more robust data from randomized controlled trials are further needed to confirm a possible association with the mortality rates.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D Deficiency / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Acta Biomed Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Abm.v92iS6.12216

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vitamin D Deficiency / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Acta Biomed Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Abm.v92iS6.12216