Kawasaki disease and increased cardiovascular risk: Is there a link to circulating glycocalyx biomarkers?
Microvasc Res
; 140: 104269, 2022 03.
Article
in English
| MEDLINE | ID: covidwho-1473424
ABSTRACT
AIMS:
Kawasaki disease (KD) is an acute systemic vasculitis with possible long-term impact of general cardio-vascular health. An endothelial glycocalyx disorder during the disease's acute phase might predispose to long-term vascular anomalies leading to endothelial dysfunction and atherosclerosis. To investigate any association between increased cardiovascular risk and endothelial glycocalyx, we assessed circulating glycocalyx components in patients with a KD history, and analysed their association with acute-phase clinical features and more importantly, with patients' current cardiovascular risk factors.METHODS:
This prospective observational cohort study included 51subjects:
31 patients with a history of KD, and 20 healthy subjects matched for age and sex. We analysed serum syndecan-1 and hyaluronan via ELISA. We assessed features reported during the acute phase of KD such as blood counts, C-reactive protein (CRP) levels and coronary artery aneurysms (CAA), and their current blood pressure and lipid markers in relation to measured glycocalyx components.RESULTS:
Our multivariate analysis revealed that hyaluronan and syndecan-1 levels were not associated with KD. However, the latter exhibited a significant association with acute-phase blood count alterations in patients with KD. Furthermore, significant interactions of hyaluronan and syndecan-1 with certain cardiovascular risk factors like blood lipids and blood pressure were only present in KD patients.CONCLUSION:
Vasculitis during KD's acute phase might predispose to a long-term endothelial glycocalyx alteration, influenced by other factors having a vascular impact such as blood pressure and circulating lipids. CLINICAL TRIAL REGISTRATION German Clinical Trials Register on 25th February 2016, DRKS00010071 https//www.drks.de/drks_web/.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronary Aneurysm
/
Glycocalyx
/
Endothelial Cells
/
Syndecan-1
/
Mucocutaneous Lymph Node Syndrome
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
/
Young adult
Language:
English
Journal:
Microvasc Res
Year:
2022
Document Type:
Article
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