Epigenetic regulation in antiviral innate immunity.
Eur J Immunol
; 51(7): 1641-1651, 2021 07.
Article
in English
| MEDLINE | ID: covidwho-1473829
ABSTRACT
Emerging life-threatening viruses have posed great challenges to public health. It is now increasingly clear that epigenetics plays a role in shaping host-virus interactions and there is a great need for a more thorough understanding of these intricate interactions through the epigenetic lens, which may represent potential therapeutic opportunities in the clinic. In this review, we highlight the current understanding of the roles of key epigenetic regulators - chromatin remodeling and histone modification - in modulating chromatin openness during host defense against virus. We also discuss how the RNA modification m6A (N6-methyladenosine) affects fundamental aspects of host-virus interactions. We conclude with future directions for uncovering more detailed functions that epigenetic regulation exerts on both host cells and viruses during infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Epigenesis, Genetic
/
Immunity, Innate
Limits:
Animals
/
Humans
Language:
English
Journal:
Eur J Immunol
Year:
2021
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS