Harnessing autophagy to fight SARS-CoV-2: An update in view of recent drug development efforts.
J Cell Biochem
; 123(2): 155-160, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1473858
ABSTRACT
Drug repurposing is an attractive option for identifying new treatment strategies, in particular in extraordinary situations of urgent need such as the current coronavirus disease 2019 (Covid-19) pandemic. Recently, the World Health Organization announced testing of three drugs as potential Covid-19 therapeutics that are known for their dampening effect on the immune system. Thus, the underlying concept of selecting these drugs is to temper the potentially life-threatening overshooting of the immune system reacting to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. This viewpoint discusses the possibility that the impact of these and other drugs on autophagy contributes to their therapeutic effect by hampering the SARS-CoV-2 life cycle.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Autophagy
/
Drug Repositioning
/
Pandemics
/
Imatinib Mesylate
/
Infliximab
/
Artesunate
/
SARS-CoV-2
/
COVID-19 Drug Treatment
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Cell Biochem
Year:
2022
Document Type:
Article
Affiliation country:
Jcb.30166
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