Association and pharmacological synergism of the triple drug therapy baricitinib/remdesivir/rhACE2 for the management of COVID-19 infection.
Naunyn Schmiedebergs Arch Pharmacol
; 395(1): 99-104, 2022 01.
Article
in English
| MEDLINE | ID: covidwho-1473988
ABSTRACT
A massive vaccination campaign against the global COVID-19 pandemic caused by SARS-CoV-2 virus began worldwide in January 2021. However, studies continue to investigate the most effective and safe drug therapies to manage the various stages of viral infection. It is critical in the therapeutic management of the patient, with ongoing COVID-19 infection, to reduce viral load and replication, and to regulate the generalized hyperinflammatory state caused by the cytokine storm that occurs in the most severe phases. Probably the right drug therapy is represented by the use of different drugs acting in different modalities and on different targets, to avoid also viral drug resistance. In this article, we describe an interesting scientific pharmacological hypothesis arising from the evidence in the literature; we believe that the association of baricitinib/remdesivir/rhACE2, administered at the right time and dose, represents an important pharmacological synergism that can be therapeutically more effective for the treatment of COVID-19 infection than the single administration of drugs and avoid the phenomenon of drug resistance caused by the virus.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Purines
/
Pyrazoles
/
Sulfonamides
/
Azetidines
/
Adenosine Monophosphate
/
Disease Management
/
Alanine
/
Angiotensin-Converting Enzyme 2
/
COVID-19 Drug Treatment
Type of study:
Diagnostic study
/
Prognostic study
/
Randomized controlled trials
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Naunyn Schmiedebergs Arch Pharmacol
Year:
2022
Document Type:
Article
Affiliation country:
S00210-021-02169-0
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