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A review of ischemic stroke in COVID-19: currently known pathophysiological mechanisms.
Tang, Xuhuan; Zheng, Fang.
  • Tang X; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
  • Zheng F; Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China. zhengfangtj@hust.edu.cn.
Neurol Sci ; 43(1): 67-79, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1474032
ABSTRACT
Coronavirus disease 2019 (COVID-19), the third type of coronavirus pneumonia after severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), is spreading widely worldwide now. This pneumonia causes not only respiratory symptoms but also multiple organ dysfunction, including thrombotic diseases such as ischemic stroke. The purpose of this review is to explore whether COVID-19 is a risk factor for ischemic stroke and its related pathophysiological mechanisms. Based on the high thrombosis rate and frequent strokes of COVID-19 patients, combined with related laboratory indicators and pathological results, the discussion is mainly from two aspects nerve invasion and endothelial dysfunction. SARS-CoV-2 can directly invade the CNS through blood-borne and neuronal retrograde pathways, causing cerebrovascular diseases. In addition, the endothelial dysfunction in COVID-19 is almost certain. Cytokine storm causes thromboinflammation, and downregulation of ACE2 leads to RAS imbalance, which eventually lead to ischemic stroke.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Brain Ischemia / Stroke / Ischemic Stroke / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Neurol Sci Journal subject: Neurology Year: 2022 Document Type: Article Affiliation country: S10072-021-05679-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Brain Ischemia / Stroke / Ischemic Stroke / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Neurol Sci Journal subject: Neurology Year: 2022 Document Type: Article Affiliation country: S10072-021-05679-0