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Mobile PCR-based surveillance for SARS-CoV-2 to reduce visiting restrictions in nursing homes during the COVID-19 pandemic: a pilot study.
Stemler, Jannik; Kramer, Theresa; Dimitriou, Vassiliki; Wieland, Ulrike; Schumacher, Sofie; Sprute, Rosanne; Oberste, Max; Wiesmüller, Gerhard; Rau, Harald; Pieper, Sally; Bethe, Ullrich; Lehmann, Clara; Hellmich, Martin; Klein, Florian; Langebartels, Georg; Cornely, Oliver A.
  • Stemler J; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Kramer T; Faculty of Medicine and University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Herderstrasse 52, 50931, Cologne, North Rhine-Westphalia, Germany.
  • Dimitriou V; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Wieland U; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Schumacher S; Faculty of Medicine and University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Herderstrasse 52, 50931, Cologne, North Rhine-Westphalia, Germany.
  • Sprute R; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Oberste M; Faculty of Medicine and University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Herderstrasse 52, 50931, Cologne, North Rhine-Westphalia, Germany.
  • Wiesmüller G; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Rau H; Faculty of Medicine and University Hospital Cologne, Institute of Virology, University of Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Pieper S; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Bethe U; Faculty of Medicine and University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Herderstrasse 52, 50931, Cologne, North Rhine-Westphalia, Germany.
  • Lehmann C; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Hellmich M; Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Klein F; Faculty of Medicine and University Hospital Cologne, Chair Translational Research, Cologne Excellence Cluster On Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Herderstrasse 52, 50931, Cologne, North Rhine-Westphalia, Germany.
  • Langebartels G; German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, North Rhine-Westphalia, Germany.
  • Cornely OA; Faculty of Medicine and University Hospital Cologne, Institute of Medical Statistics and Computational Biology (IMSB), University of Cologne, Cologne, North Rhine-Westphalia, Germany.
Infection ; 50(3): 607-616, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1474165
ABSTRACT

PURPOSE:

Residents in nursing homes for the elderly (NH) are at high risk for death from COVID-19. We investigated whether repeated non-mandatory RT-PCR SARS-CoV-2 surveillance of NH staff and visitors reduces COVID-19 incidence rates in NH residents and allows to reduce visiting restrictions.

METHODS:

This pilot study at the beginning of the COVID-19 pandemic compared a surveillance approach of regular, twice-weekly voluntary PCR testing of health-care workers (HCW) and visitors in interventional NH (INH) with a setting without regular testing in control NH (CNH). Residents were not tested routinely within this study. Testing was performed in a mobile testing site with same-day result reporting. SARS-CoV-2 incidence among residents in both INH and CNH was the primary endpoint; secondary endpoints being SARS-CoV-2 infection among visitors and HCW in INH.

RESULTS:

Two INH and two CNH participated between October and December, 2020. At INH1, 787 tests of HCW and 350 tests of visitors were performed, accounting for 18.1% (n = 1930) of visits. At INH2, 78 tests of HCW and 372 tests of visitors were done, i.e., 30.5% (n = 1220) of visits. At the two INH 23 HCW and three visitors tested positive for SARS-CoV-2. COVID-19 outbreaks occurred among residents in INH1 (identified through study testing) and in CNH1. Utilization of voluntary testing was low.

CONCLUSION:

In a real-world setting without available rapid testing, voluntary RT-PCR SARS-CoV-2 testing of HCW and visitors does not prevent COVID-19 outbreaks in NH. Complete, non-selective testing for these groups should be instituted before visiting restrictions can be reduced. TRIAL REGISTRATION The study has been registered at ClinicalTrials.gov with the identifier NCT04933981.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Humans Language: English Journal: Infection Year: 2022 Document Type: Article Affiliation country: S15010-021-01716-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Humans Language: English Journal: Infection Year: 2022 Document Type: Article Affiliation country: S15010-021-01716-4