Uracil derivatives as non-nucleoside inhibitors of viral infections

ABSTRACT

Viral infections are one of the important factors that influence the development of mankind. In recent decades, there has been a steady increase in the number of infectious diseases of viral etiology. This is due to the peculiarities of demography and human behavior, uncontrolled urbanization in developing countries, intensification of international travel and trade, lack of effective sanitation, environmental pollution, lack of programs to combat vectors of various diseases, adaptation of viruses themselves to new conditions, the emergence of a large number of refugees, and the shortcomings of public health measures. Such a tense situation is seen as a new challenge not only to modern medicine, but also to humanity as a whole. One of the ways to overcome this problem is the search and development of new highly effective antiviral drugs to combat socially significant diseases. This chapter summarizes the literature data on the study of uracil derivatives, acting as non-nucleoside inhibitors against various RNA and DNA viruses.