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In-vivo evidence of systemic endothelial vascular dysfunction in COVID-19.
Mejia-Renteria, Hernan; Travieso, Alejandro; Sagir, Adam; Martínez-Gómez, Eduardo; Carrascosa-Granada, Angela; Toya, Takumi; Núñez-Gil, Iván J; Estrada, Vicente; Lerman, Amir; Escaned, Javier.
  • Mejia-Renteria H; Hospital Clínico San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid, Spain. Electronic address: hmejiarenteria@gmail.com.
  • Travieso A; Hospital Clínico San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid, Spain.
  • Sagir A; Bar-Ilan University, Faculty of Medicine, Safed, Israel.
  • Martínez-Gómez E; Hospital Clínico San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid, Spain.
  • Carrascosa-Granada A; Hospital Clínico San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid, Spain.
  • Toya T; Mayo Clinic, Rochester, MN, United States.
  • Núñez-Gil IJ; Hospital Clínico San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid, Spain.
  • Estrada V; Hospital Clínico San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid, Spain.
  • Lerman A; Mayo Clinic, Rochester, MN, United States.
  • Escaned J; Hospital Clínico San Carlos, IDISSC and Universidad Complutense de Madrid, Madrid, Spain.
Int J Cardiol ; 345: 153-155, 2021 12 15.
Article in English | MEDLINE | ID: covidwho-1474609
ABSTRACT

BACKGROUND:

Endothelial dysfunction is one of the underlying mechanisms to vascular and cardiac complications in patients with COVID-19. We sought to investigate the systemic vascular endothelial function and its temporal changes in COVID-19 patients from a non-invasive approach with reactive hyperemia peripheral arterial tonometry (PAT).

METHODS:

This is a prospective, observational, case-control and blinded study. The population was comprised by 3 groups patients investigated during acute COVID-19 (group 1), patients investigated during past COVID-19 (group 2), and controls 11 matched to COVID-19 patients by demographics and cardiovascular risk factors (group 3). The natural logarithmic scaled reactive hyperemia index (LnRHI), a measure of endothelium-mediated dilation of peripheral arteries, was obtained in all the participants and compared between study groups.

RESULTS:

144 participants were enrolled (72 COVID-19 patients and 72 matched controls). Median time from COVID-19 symptoms to PAT assessment was 9.5 and 101.5 days in groups 1 and 2, respectively. LnRHI was significantly lower in group 2 compared to both group 1 and controls (0.53 ± 0.23 group 2 vs. 0.72 ± 0.26 group 1, p = 0.0043; and 0.79 ± 0.23 in group 3, p < 0.0001). In addition, within group 1, it was observed a markedly decrease in LnRHI from acute COVID-19 to post infection stage (0.73 ± 0.23 vs. 0.42 ± 0.26, p = 0.0042).

CONCLUSIONS:

This study suggests a deleterious effect of SARS-CoV-2 infection on systemic vascular endothelial function. These findings open new venues to investigate the clinical implication and prognostic role of vascular endothelial dysfunction in COVID-19 patients and post-COVID syndrome using non-invasive techniques.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vascular Diseases / COVID-19 / Hyperemia Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Int J Cardiol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vascular Diseases / COVID-19 / Hyperemia Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Int J Cardiol Year: 2021 Document Type: Article