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The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?
Boyton, Rosemary J; Altmann, Daniel M.
  • Boyton RJ; Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK. r.boyton@imperial.ac.uk.
  • Altmann DM; Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St. Thomas' NHS Foundation Trust, London, UK. r.boyton@imperial.ac.uk.
Nat Rev Immunol ; 21(12): 762-768, 2021 12.
Article in English | MEDLINE | ID: covidwho-1475303
ABSTRACT
An important challenge during the COVID-19 pandemic has been to understand asymptomatic disease and the extent to which this may be a source of transmission. As asymptomatic disease is by definition hard to screen for, there is a lack of clarity about this aspect of the COVID-19 spectrum. Studies have considered whether the prevalence of asymptomatic disease is determined by differences in age, demographics, viral load, duration of shedding, and magnitude or durability of immunity. It is clear that adaptive immunity is strongly activated during asymptomatic infection, but some features of the T cell and antibody response may differ from those in symptomatic disease. Areas that need greater clarity include the extent to which asymptomatic disease leads to persistent symptoms (long COVID), and the quality, quantity and durability of immune priming required to confer subsequent protection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Infections / COVID-19 / Immunologic Memory Type of study: Observational study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Nat Rev Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41577-021-00631-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Infections / COVID-19 / Immunologic Memory Type of study: Observational study Topics: Long Covid Limits: Animals / Humans Language: English Journal: Nat Rev Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41577-021-00631-x