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A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection.
Andreakos, Evangelos; Abel, Laurent; Vinh, Donald C; Kaja, Elzbieta; Drolet, Beth A; Zhang, Qian; O'Farrelly, Cliona; Novelli, Giuseppe; Rodríguez-Gallego, Carlos; Haerynck, Filomeen; Prando, Carolina; Pujol, Aurora; Su, Helen C; Casanova, Jean-Laurent; Spaan, András N.
  • Andreakos E; Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece. vandreakos@bioacademy.gr.
  • Abel L; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
  • Vinh DC; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
  • Kaja E; University of Paris, Imagine Institute, Paris, France.
  • Drolet BA; Department of Medicine, Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.
  • Zhang Q; Infectious Disease Susceptibility Program, Research Institute, McGill University Health Centre, Montréal, Québec, Canada.
  • O'Farrelly C; MNM Diagnostics Inc., Lewes, DE, USA.
  • Novelli G; Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
  • Rodríguez-Gallego C; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
  • Haerynck F; Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
  • Prando C; University of Paris, Imagine Institute, Paris, France.
  • Pujol A; Comparative Immunology Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  • Su HC; Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Las Palmas, Spain.
  • Casanova JL; Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Las Palmas, Spain.
  • Spaan AN; Department of Pediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium.
Nat Immunol ; 23(2): 159-164, 2022 02.
Article in English | MEDLINE | ID: covidwho-1475313
ABSTRACT
SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genetic Predisposition to Disease / Disease Resistance / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Nat Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: S41590-021-01030-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genetic Predisposition to Disease / Disease Resistance / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Nat Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: S41590-021-01030-z