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The Effect of SARS-CoV-2 on the Spleen and T Lymphocytes.
Xie, Lixia; Lin, Yuanlan; Deng, Yushu; Lei, Bin.
  • Xie L; Department of Ultrasound, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Lin Y; Department of Ultrasound, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Deng Y; Department of Neurosurgery, Hospital of Integrated Traditional Chinese Medicine & Western Medicine, Southern Medical University, Guangzhou, China.
  • Lei B; Department of Urology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Viral Immunol ; 34(6): 416-420, 2021.
Article in English | MEDLINE | ID: covidwho-1475758
Semantic information from SemMedBD (by NLM)
1. Spleen LOCATION_OF 2019 novel coronavirus
Subject
Spleen
Predicate
LOCATION_OF
Object
2019 novel coronavirus
2. T-Lymphocyte LOCATION_OF 2019 novel coronavirus
Subject
T-Lymphocyte
Predicate
LOCATION_OF
Object
2019 novel coronavirus
3. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
4. Organ LOCATION_OF 2019 novel coronavirus
Subject
Organ
Predicate
LOCATION_OF
Object
2019 novel coronavirus
5. Organ PART_OF Patients
Subject
Organ
Predicate
PART_OF
Object
Patients
6. IMPACT gene PART_OF 2019 novel coronavirus
Subject
IMPACT gene
Predicate
PART_OF
Object
2019 novel coronavirus
7. Flow Cytometry METHOD_OF Orbital B scan
Subject
Flow Cytometry
Predicate
METHOD_OF
Object
Orbital B scan
8. T-Lymphocyte PART_OF Patients
Subject
T-Lymphocyte
Predicate
PART_OF
Object
Patients
9. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
10. Spleen LOCATION_OF 2019 novel coronavirus
Subject
Spleen
Predicate
LOCATION_OF
Object
2019 novel coronavirus
11. T-Lymphocyte LOCATION_OF 2019 novel coronavirus
Subject
T-Lymphocyte
Predicate
LOCATION_OF
Object
2019 novel coronavirus
12. 2019 novel coronavirus CAUSES COVID-19
Subject
2019 novel coronavirus
Predicate
CAUSES
Object
COVID-19
13. Organ LOCATION_OF 2019 novel coronavirus
Subject
Organ
Predicate
LOCATION_OF
Object
2019 novel coronavirus
14. Organ PART_OF Patients
Subject
Organ
Predicate
PART_OF
Object
Patients
15. IMPACT gene PART_OF 2019 novel coronavirus
Subject
IMPACT gene
Predicate
PART_OF
Object
2019 novel coronavirus
16. Flow Cytometry METHOD_OF Orbital B scan
Subject
Flow Cytometry
Predicate
METHOD_OF
Object
Orbital B scan
17. T-Lymphocyte PART_OF Patients
Subject
T-Lymphocyte
Predicate
PART_OF
Object
Patients
18. Pneumonia PROCESS_OF Patients
Subject
Pneumonia
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has infected millions of individuals in the world. However, the long-term effect of SARS-CoV-2 on the organs of recovered patients remains unclear. This study is to evaluate the impact of SARS-CoV-2 on the spleen and T lymphocytes. Seventy-six patients recovered from COVID-19, including 66 cases of moderate pneumonia and 10 cases of severe pneumonia were enrolled in the observation group. The control group consisted of 55 age-matched healthy subjects. The thickness and length of spleen were measured by using B-ultrasound and the levels of T lymphocytes were detected by flow cytometry. Results showed that the mean length of spleen in the observation group was 89.57 ± 11.49 mm, which was significantly reduced compared with that in the control group (103.82 ± 11.29 mm, p < 0.001). The mean thicknesses of spleen between observation group and control group were 29.97 ± 4.04 mm and 32.45 ± 4.49 mm, respectively, and the difference was significant (p < 0.001). However, no significant difference was observed in the size of spleen between common pneumonia and severe pneumonia (p > 0.05). In addition, the decreased count of T lymphocyte was observed in part of recovered patients. The counts of T suppressor lymphocytes in patients with severe pneumonia were significantly decreased compared with those with moderate pneumonia (p = 0.005). Therefore, these data indicate that SARS-CoV-2 infection affects the size of spleen and T lymphocytes.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Spleen / T-Lymphocytes / SARS-CoV-2 / COVID-19 Subject: Spleen / T-Lymphocytes / SARS-CoV-2 / COVID-19 Type of study: Observational study Language: English Journal: Viral Immunol Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Spleen / T-Lymphocytes / SARS-CoV-2 / COVID-19 Subject: Spleen / T-Lymphocytes / SARS-CoV-2 / COVID-19 Type of study: Observational study Language: English Journal: Viral Immunol Year: 2021
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