Use of traditional Chinese medicine as an adjunctive treatment for COVID-19: A systematic review and meta-analysis.
Medicine (Baltimore)
; 100(30): e26641, 2021 Jul 30.
Article
in English
| MEDLINE | ID: covidwho-1475904
ABSTRACT
BACKGROUND:
This review aims to evaluate the supportive effects of frequently used traditional Chinese medicine (TCM) for the treatment of coronavirus disease 2019 (COVID-19).METHODS:
Five databases were searched through July 7, 2020. Randomized controlled trials investigating the efficacy of TCM for use in the treatment of COVID-19 were included. Newcastle-Ottawa Scale (NOS) and modified Jadad score were used for the evaluation of the methodological quality of the included studies. Weighted mean difference, odds ratio (OR), and 95% confidence interval (95% CI) were calculated for pooling out results. Data were extracted for conducting a meta-analysis using STATA version 12.0.RESULTS:
Eight studies with a total of 750 patients were included in this meta-analysis. All included trial groups involved treatment with TCM and Western medicine, while the control groups were treated only with Western medicine. The intervention therapy significantly improved the overall effective rate (nâ=â346, ORâ=â2.5, 95% CIsâ=â1.46-4.29), fever symptom disappearance rate (nâ=â436; ORâ=â3.6; 95% CIsâ=â2.13-6.08), fatigue symptom disappearance rate (nâ=â436; ORâ=â3.04; 95% CIsâ=â1.76-5.26), cough symptom disappearance rate (nâ=â436; ORâ=â2.91; 95% CIsâ=â1.36-6.19), and sputum production reduction (nâ=â436; ORâ=â5.51; 95% CIsâ=â1.94-15.64). Based on the Newcastle-Ottawa Scale assessment, 6 studies received a score of 4, and 1 study achieved a score of 5. One study was assessed using the modified Jadad score, achieving a score of 6.CONCLUSIONS:
The integration of TCM with Western medicine has significantly improved the treatment for COVID-19 patients compared to Western medicine treatment alone. Combined therapy using TCM and Western medicine revealed the potential adjunctive role of TCM in treating COVID-19. However, high-quality clinical studies are still required to further evaluate the efficacy and safety of TCM in the treatment of COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Drugs, Chinese Herbal
/
COVID-19 Drug Treatment
/
Medicine, Chinese Traditional
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Traditional medicine
Limits:
Humans
Language:
English
Journal:
Medicine (Baltimore)
Year:
2021
Document Type:
Article
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