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Complicated and persistent severe COVID-19 pneumonia in a recipient of allogeneic haematopoietic stem cell transplant.
Lazzari, Lorenzo; Oltolini, Chiara; Ciceri, Fabio; Giglio, Fabio.
  • Lazzari L; Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milano, Italy lazzari.lorenzo@hsr.it.
  • Oltolini C; Department of Infectious Diseases, IRCCS Ospedale San Raffaele, Milano, Italy.
  • Ciceri F; Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
  • Giglio F; Hematology and Bone Marrow Transplantation Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
BMJ Case Rep ; 14(10)2021 Oct 19.
Article in English | MEDLINE | ID: covidwho-1476413
ABSTRACT
We describe the case of a 45-year-old man affected by T-cell acute lymphoblastic leukaemia and diagnosed with COVID-19 early after an allogeneic haematopoietic stem cell transplant. The infectious disease was characterised by a severe and prolonged course, further complicated by a spontaneous pneumomediastinum and pneumopericardium. We successfully treated this patient with the antiviral drug remdesivir associated with two courses of COVID-19 convalescent plasma. This case report represents a good example of the typical clinical course of COVID-19 in severely immunosuppressed patients and gives evidence that in this population only a prompt treatment directed towards viral clearance can face the absence of a valid immune reactivity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Hematopoietic Stem Cell Transplantation / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-245992

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Hematopoietic Stem Cell Transplantation / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Bcr-2021-245992