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Prevention of SARS-CoV-2 (COVID-19) transmission in residential aged care using ultraviolet light (PETRA): a two-arm crossover randomised controlled trial protocol.
Brass, Amanda; Shoubridge, Andrew P; Crotty, Maria; Morawska, Lidia; Bell, Scott C; Qiao, Ming; Woodman, Richard J; Whitehead, Craig; Inacio, Maria C; Miller, Caroline; Corlis, Megan; Larby, Nicolas; Elms, Levi; Sims, Sarah K; Taylor, Steven L; Flynn, Erin; Papanicolas, Lito E; Rogers, Geraint B.
  • Brass A; The South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
  • Shoubridge AP; The Microbiome and Host Health Programme, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.
  • Crotty M; The South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia. andrew.shoubridge@sahmri.com.
  • Morawska L; The Microbiome and Host Health Programme, College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia. andrew.shoubridge@sahmri.com.
  • Bell SC; The South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
  • Qiao M; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
  • Woodman RJ; Southern Adelaide Local Health Network, SA Health, Adelaide, SA, Australia.
  • Whitehead C; International Laboratory for Air Quality and Health, Queensland University of Technology, Brisbane, QLD, Australia.
  • Inacio MC; The Prince Charles Hospital, Brisbane, QLD, Australia.
  • Miller C; Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
  • Corlis M; SA Pathology, SA Health, Adelaide, SA, Australia.
  • Larby N; The South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
  • Elms L; Flinders Centre for Epidemiology and Biostatistics, Flinders University, Adelaide, SA, Australia.
  • Sims SK; The South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
  • Taylor SL; College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia.
  • Flynn E; Southern Adelaide Local Health Network, SA Health, Adelaide, SA, Australia.
  • Papanicolas LE; The South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia.
  • Rogers GB; Registy of Senior Australians, SAHMRI, Adelaide, SA, Australia.
BMC Infect Dis ; 21(1): 967, 2021 Sep 17.
Article in English | MEDLINE | ID: covidwho-1477291
ABSTRACT

BACKGROUND:

SARS-CoV-2 poses a considerable threat to those living in residential aged care facilities (RACF). RACF COVID-19 outbreaks have been characterised by the rapid spread of infection and high rates of severe disease and associated mortality. Despite a growing body of evidence supporting airborne transmission of SARS-CoV-2, current infection control measures in RACF including hand hygiene, social distancing, and sterilisation of surfaces, focus on contact and droplet transmission. Germicidal ultraviolet (GUV) light has been used widely to prevent airborne pathogen transmission. Our aim is to investigate the efficacy of GUV technology in reducing the risk of SARS-CoV-2 infection in RACF.

METHODS:

A multicentre, two-arm double-crossover, randomised controlled trial will be conducted to determine the efficacy of GUV devices to reduce respiratory viral transmission in RACF, as an adjunct to existing infection control measures. The study will be conducted in partnership with three aged care providers in metropolitan and regional South Australia. RACF will be separated into paired within-site zones, then randomised to intervention order (GUV or control). The initial 6-week period will be followed by a 2-week washout before crossover to the second 6-week period. After accounting for estimated within-zone and within-facility correlations of infection, and baseline infection rates (10 per 100 person-days), a sample size of n = 8 zones (n = 40 residents/zone) will provide 89% power to detect a 50% reduction in symptomatic infection rate. The primary outcome will be the incidence rate ratio of combined symptomatic respiratory infections for intervention versus control. Secondary outcomes include incidence rates of hospitalisation for complications associated with respiratory infection; respiratory virus detection in facility air and fomite samples; rates of laboratory confirmed respiratory illnesses and genomic characteristics.

DISCUSSION:

Measures that can be deployed rapidly into RACF, that avoid the requirement for changes in resident and staff behaviour, and that are effective in reducing the risk of airborne SARS-CoV-2 transmission, would provide considerable benefit in safeguarding a highly vulnerable population. In addition, such measures might substantially reduce rates of other respiratory viruses, which contribute considerably to resident morbidity and mortality. Trial registration Australian and New Zealand Clinical Trials Registry ACTRN12621000567820 (registered on 14th May, 2021).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Randomized controlled trials Limits: Aged / Humans Country/Region as subject: Oceania Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06659-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Controlled clinical trial / Randomized controlled trials Limits: Aged / Humans Country/Region as subject: Oceania Language: English Journal: BMC Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: S12879-021-06659-7