Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19.
Cancer Cell Int
; 21(1): 431, 2021 Aug 16.
Article
in English
| MEDLINE | ID: covidwho-1477423
ABSTRACT
Recent studies on the pathophysiology of COVID-19 are indicating that the Angiotensin convertase enzyme 2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) can act as a major component in the fusion of SARS-Cov-2 with target cells. It has also been observed that the expression of ACE-2 and TMPRSS2 can be altered in malignancies. Shedding light on this matter could be crucial since the COVID-19 pandemic interfered with many gastrointestinal cancer screening programs. Herein we discuss the possibility of severe forms of COVID-19 in patients with gastrointestinal cancers due to the gastrointestinal entry route of SARS-CoV-2 into the human body. The disruption of cancer screening programs caused by the current COVID-19 pandemic could therefore have massive negative health impact on patients affected by gastrointestinal malignancies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Cancer Cell Int
Year:
2021
Document Type:
Article
Affiliation country:
S12935-021-02129-x
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