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Acute Pancreatitis and COVID-19: A Single-Center Experience.
Annunziata, Anna; Coppola, Antonietta; Andreozzi, Paolo; Lanza, Maurizia; Simioli, Francesca; Carannante, Novella; Di Somma, Camilla; Di Micco, Pierpaolo; Fiorentino, Giuseppe.
  • Annunziata A; Department of Critic Area, I Unit COVID, Monaldi-Cotugno Hospital, Naples, Italy.
  • Coppola A; Department of Critic Area, I Unit COVID, Monaldi-Cotugno Hospital, Naples, Italy.
  • Andreozzi P; Endoscopy and Gastroenterology Unit, Marcianise Hospital, Asl Caserta, Caserta, Italy.
  • Lanza M; Department of Critic Area, I Unit COVID, Monaldi-Cotugno Hospital, Naples, Italy.
  • Simioli F; Department of Critic Area, I Unit COVID, Monaldi-Cotugno Hospital, Naples, Italy.
  • Carannante N; First Division Infectious Disease, Cotugno Hospital, Naples, Italy.
  • Di Somma C; Department of Critic Area, I Unit COVID, Monaldi-Cotugno Hospital, Naples, Italy.
  • Di Micco P; UOC Internal Medicine, Fatebenefratelli Hospital, Naples, Italy.
  • Fiorentino G; Department of Critic Area, I Unit COVID, Monaldi-Cotugno Hospital, Naples, Italy.
J Multidiscip Healthc ; 14: 2857-2861, 2021.
Article in English | MEDLINE | ID: covidwho-1477661
ABSTRACT
Gastrointestinal involvement in SARS-CoV-2 disease (COVID-19) can occur and evolve fatally. Reports are emerging that SARS-CoV-2 virus attacks the pancreatic cells, causing the boost of amylase and lipase serum activity and rarely frank pancreatitis. We retrospectively assessed all the patients admitted to the respiratory sub-intensive care and evaluated pancreatitis cases and their course. In our study, we included all patients admitted to our respiratory sub-intensive care unit from 1st to 30th November. All patients had a confirmed diagnosis of COVID-19 and a CT finding of interstitial pneumonia associated with signs of respiratory failure. We observed the course and evaluated who developed acute pancreatitis according to standard definitions. In this study, etiology of acute pancreatitis was defined on the basis of risk factors (ie, biliary pancreatitis was defined in presence of common bile duct stone or sludge at CT or MR). According to the Revised Atlanta Classification, we diagnosed and classified the patients and evaluated the radiological severity according to the Balthazar index and a computed tomography severity index. We found that 19% (15 of 78 patients) met the criteria for acute pancreatitis. The mortality rate among patients with pancreatitis was 20%. Interestingly, in our population, cholelithiasis' imaging findings were found in only 7% of the patients, whereas no patient-reported alcohol consumption. Considering that alcohol and biliary stones represent the two major causes of AP in the general population, it is reasonable to hypothesize that SARS-CoV-2 could play a role in the etiology of acute pancreatitis in a subgroup of these patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Risk factors Language: English Journal: J Multidiscip Healthc Year: 2021 Document Type: Article Affiliation country: JMDH.S334835

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Risk factors Language: English Journal: J Multidiscip Healthc Year: 2021 Document Type: Article Affiliation country: JMDH.S334835